The Influence of Bitter-taste Receptor (TAS2R) Expression in Pharmacological Response to Chloroquine in Obese Patients with COVID-19

Overview

Journal Clinics (Sao Paulo)

Publisher Elsevier

Specialty General Medicine

Date 2020 Sep 3

PMID 32876108

Citations 3

Authors

Ligia Moriguchi Watanabe

Izabella Ferreira Pires

Natalia Yumi Noronha

Marcela Augusta de Souza Pinhel

Carla Barbosa Nonino

Affiliations

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References

Lu P, Zhang C, Lifshitz L, Zhuge R . Extraoral bitter taste receptors in health and disease. J Gen Physiol. 2017; 149(2):181-197. PMC: 5299619. DOI: 10.1085/jgp.201611637. View

Devaux C, Rolain J, Colson P, Raoult D . New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?. Int J Antimicrob Agents. 2020; 55(5):105938. PMC: 7118659. DOI: 10.1016/j.ijantimicag.2020.105938. View

Karalis V, Ismailos G, Karatza E . Chloroquine dosage regimens in patients with COVID-19: Safety risks and optimization using simulations. Saf Sci. 2020; 129:104842. PMC: 7241328. DOI: 10.1016/j.ssci.2020.104842. View

Petri M, ElKhalifa M, Li J, Magder L, Goldman D . Hydroxychloroquine Blood Levels Predict Hydroxychloroquine Retinopathy. Arthritis Rheumatol. 2019; 72(3):448-453. PMC: 7050401. DOI: 10.1002/art.41121. View

Nayak A, Shah S, Michael J, Deshpande D . Bitter Taste Receptors for Asthma Therapeutics. Front Physiol. 2019; 10:884. PMC: 6647873. DOI: 10.3389/fphys.2019.00884. View

Petrilli C, Jones S, Yang J, Rajagopalan H, ODonnell L, Chernyak Y . Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020; 369:m1966. PMC: 7243801. DOI: 10.1136/bmj.m1966. View

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223):497-506. PMC: 7159299. DOI: 10.1016/S0140-6736(20)30183-5. View

Kannan S, Shaik Syed Ali P, Sheeza A, Hemalatha K . COVID-19 (Novel Coronavirus 2019) - recent trends. Eur Rev Med Pharmacol Sci. 2020; 24(4):2006-2011. DOI: 10.26355/eurrev_202002_20378. View

Zhai P, Ding Y, Wu X, Long J, Zhong Y, Li Y . The epidemiology, diagnosis and treatment of COVID-19. Int J Antimicrob Agents. 2020; 55(5):105955. PMC: 7138178. DOI: 10.1016/j.ijantimicag.2020.105955. View

10.

Chan J, Kok K, Zhu Z, Chu H, To K, Yuan S . Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020; 9(1):221-236. PMC: 7067204. DOI: 10.1080/22221751.2020.1719902. View

11.

De Lorenzo A, Tarsitano M, Falcone C, Di Renzo L, Romano L, Macheda S . Fat mass affects nutritional status of ICU COVID-19 patients. J Transl Med. 2020; 18(1):299. PMC: 7397427. DOI: 10.1186/s12967-020-02464-z. View

12.

Smit C, Peeters M, van den Anker J, Knibbe C . Chloroquine for SARS-CoV-2: Implications of Its Unique Pharmacokinetic and Safety Properties. Clin Pharmacokinet. 2020; 59(6):659-669. PMC: 7165255. DOI: 10.1007/s40262-020-00891-1. View

13.

Grassin-Delyle S, Salvator H, Mantov N, Abrial C, Brollo M, Faisy C . Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists. Front Physiol. 2019; 10:1267. PMC: 6783802. DOI: 10.3389/fphys.2019.01267. View

14.

Li X, Zhang C, Liu L, Gu M . Existing bitter medicines for fighting 2019-nCoV-associated infectious diseases. FASEB J. 2020; 34(5):6008-6016. PMC: 7262065. DOI: 10.1096/fj.202000502. View

15.

Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M . Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020; 30(3):269-271. PMC: 7054408. DOI: 10.1038/s41422-020-0282-0. View

16.

Rothan H, Byrareddy S . The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020; 109:102433. PMC: 7127067. DOI: 10.1016/j.jaut.2020.102433. View

17.

Zores F, Rebeaud M . COVID and the Renin-Angiotensin System: Are Hypertension or Its Treatments Deleterious?. Front Cardiovasc Med. 2020; 7:71. PMC: 7191060. DOI: 10.3389/fcvm.2020.00071. View

18.

Abu-Raya B . Predictors of Refractory Coronavirus Disease (COVID-19) Pneumonia. Clin Infect Dis. 2020; 71(15):895-896. PMC: 7184398. DOI: 10.1093/cid/ciaa409. View

19.

Onder G, Rezza G, Brusaferro S . Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA. 2020; 323(18):1775-1776. DOI: 10.1001/jama.2020.4683. View

20.

Wang Q, Liszt K, Depoortere I . Extra-oral bitter taste receptors: New targets against obesity?. Peptides. 2020; 127:170284. DOI: 10.1016/j.peptides.2020.170284. View