Gracilosulfates A-G, Monosulfated Polyoxygenated Steroids from the Marine Sponge

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2020 Sep 3

PMID 32872590

Citations 8

Authors

Larisa K Shubina

Tatyana N Makarieva

Vladimir A Denisenko

Roman S Popov

Sergey A Dyshlovoy

Boris B Grebnev

Pavel S Dmitrenok

Gunhild von Amsberg

Valentin A Stonik

Affiliations

Soon will be listed here.

Abstract

Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (-), possessing 3--sulfonato, 56 epoxy (or 5(6)-dehydro), and 4,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Their structures were determined by NMR and MS methods. The compounds , and inhibited the expression of prostate-specific antigen (PSA) in 22Rv1 tumor cells.

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