3D Printed Polycaprolactone/Gelatin/Bacterial Cellulose/Hydroxyapatite Composite Scaffold for Bone Tissue Engineering

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2020 Sep 3

PMID 32872547

Citations 32

Authors

Abdullah M Cakmak

Semra Unal

Ali Sahin

Faik N Oktar

Mustafa Sengor

Nazmi Ekren

Oguzhan Gunduz

Deepak M Kalaskar

Affiliations

Soon will be listed here.

Abstract

Three-dimensional (3D) printing application is a promising method for bone tissue engineering. For enhanced bone tissue regeneration, it is essential to have printable composite materials with appealing properties such as construct porous, mechanical strength, thermal properties, controlled degradation rates, and the presence of bioactive materials. In this study, polycaprolactone (PCL), gelatin (GEL), bacterial cellulose (BC), and different hydroxyapatite (HA) concentrations were used to fabricate a novel PCL/GEL/BC/HA composite scaffold using 3D printing method for bone tissue engineering applications. Pore structure, mechanical, thermal, and chemical analyses were evaluated. 3D scaffolds with an ideal pore size (~300 µm) for use in bone tissue engineering were generated. The addition of both bacterial cellulose (BC) and hydroxyapatite (HA) into PCL/GEL scaffold increased cell proliferation and attachment. PCL/GEL/BC/HA composite scaffolds provide a potential for bone tissue engineering applications.

Citing Articles

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Facile fabrication of linezolid/strontium coated hydroxyapatite/graphene oxide nanocomposite for osteoporotic bone defect.

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Bacterial Cellulose: A Sustainable Source for Hydrogels and 3D-Printed Scaffolds for Tissue Engineering.

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