Fatal Outcome of Ilheus Virus in the Cerebrospinal Fluid of a Patient Diagnosed with Encephalitis

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2020 Sep 3

PMID 32872425

Citations 16

Authors

Bruno H G A Milhim

Cassia F Estofolete

Leonardo C da Rocha

Elisabete Liso

Vania M S Brienze

Nikos Vasilakis

Ana C B Terzian

Mauricio L Nogueira

Affiliations

Soon will be listed here.

Abstract

Ilheus virus is an arbovirus with the potential for central nervous system involvement. Accurate diagnosis is a challenge due to similar clinical symptoms and serologic cross-reactivity with other flaviviruses. Here, we describe the first documented case of a fatal outcome following the identification of Ilheus virus in the cerebrospinal fluid (CSF) of a patient with cerebral encephalitis in Brazil.

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References

AITKEN T, Anderson C, DOWNS W . The isolation of Ilhéus virus from wild caught forest mosquitoes in Trinidad. Am J Trop Med Hyg. 1956; 5(4):621-5. DOI: 10.4269/ajtmh.1956.5.621. View

DE RODANICHE E, Galindo P . Isolation of Ilhéus virus from Sabethes chloropterus captured in Guatemala in 1956. Am J Trop Med Hyg. 1957; 6(4):686-7. DOI: 10.4269/ajtmh.1957.6.686. View

CAUSEY O, Theiler M . Virus antibody survey on sera of residents of the Amazon Valley in Brazil. Am J Trop Med Hyg. 1958; 7(1):36-41. DOI: 10.4269/ajtmh.1958.7.36. View

Chiaravalloti-Neto F, Pereira M, Favaro E, Dibo M, Mondini A, Rodrigues-Junior A . Assessment of the relationship between entomologic indicators of Aedes aegypti and the epidemic occurrence of dengue virus 3 in a susceptible population, São José do Rio Preto, São Paulo, Brazil. Acta Trop. 2014; 142:167-77. DOI: 10.1016/j.actatropica.2014.11.017. View

Figueiredo L . The Brazilian flaviviruses. Microbes Infect. 2000; 2(13):1643-9. DOI: 10.1016/s1286-4579(00)01320-4. View

Ferreira I, Pereira L, Rocco I, Marti A, de Souza L, Iversson L . Surveillance of arbovirus infections in the Atlantic Forest Region, State of São Paulo, Brazil. I. Detection of hemagglutination-inhibiting antibodies in wild birds between 1978 and 1990. Rev Inst Med Trop Sao Paulo. 1994; 36(3):265-74. DOI: 10.1590/s0036-46651994000300011. View

SANGER F, Nicklen S, Coulson A . DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977; 74(12):5463-7. PMC: 431765. DOI: 10.1073/pnas.74.12.5463. View

de Almeida Araujo S, Cordeiro T, Rolim Belisario A, Araujo R, Marinho P, Kroon E . First report of collapsing variant of focal segmental glomerulosclerosis triggered by arbovirus: dengue and Zika virus infection. Clin Kidney J. 2019; 12(3):355-361. PMC: 6543975. DOI: 10.1093/ckj/sfy104. View

Bosch I, de Puig H, Hiley M, Carre-Camps M, Perdomo-Celis F, Narvaez C . Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum. Sci Transl Med. 2017; 9(409). PMC: 6612058. DOI: 10.1126/scitranslmed.aan1589. View

10.

Drumond B, Mondini A, Schmidt D, de Morais Bronzoni R, Bosch I, Nogueira M . Circulation of different lineages of Dengue virus 2, genotype American/Asian in Brazil: dynamics and molecular and phylogenetic characterization. PLoS One. 2013; 8(3):e59422. PMC: 3606110. DOI: 10.1371/journal.pone.0059422. View

11.

Pereira L, Suzuki A, Coimbra T, de Souza R, Chamelet E . [Ilheus arbovirus in wild birds (Sporophila caerulescens and Molothrus bonariensis)]. Rev Saude Publica. 2001; 35(2):119-23. DOI: 10.1590/s0034-89102001000200003. View

12.

KOPROWSKI H, Hughes T . The virus of Ilhéus encephalitis; physical properties, pathogenicity and cultivation. J Immunol. 2010; 54(4):371-85. View

13.

DE RODANICHE E . Isolation of the virus of IIhéus encephalitis from mosquitoes of the genus Psorophora captured in Honduras. Am J Trop Med Hyg. 1956; 5(5):797-801. DOI: 10.4269/ajtmh.1956.5.797. View

14.

Panon G, Fauran P, Digoutte J . [Isolation of Ilheus virus in french Guyana]. Bull Soc Pathol Exot Filiales. 1979; 72(4):315-8. View

15.

Terzian A, Mondini A, Bronzoni R, Drumond B, Ferro B, Cabrera E . Detection of Saint Louis encephalitis virus in dengue-suspected cases during a dengue 3 outbreak. Vector Borne Zoonotic Dis. 2010; 11(3):291-300. DOI: 10.1089/vbz.2009.0200. View

16.

Nassar E, Coimbra T, Rocco I, Pereira L, Ferreira I, de Souza L . Human disease caused by an arbovirus closely related to Ilheus virus: report of five cases. Intervirology. 1997; 40(4):247-52. DOI: 10.1159/000150554. View

17.

Johnson B, Cruz C, Felices V, Espinoza W, Manock S, Guevara C . Ilheus virus isolate from a human, Ecuador. Emerg Infect Dis. 2007; 13(6):956-8. PMC: 2792834. DOI: 10.3201/eid1306.070118. View

18.

Parra B, Lizarazo J, Jimenez-Arango J, Zea-Vera A, Gonzalez-Manrique G, Vargas J . Guillain-Barré Syndrome Associated with Zika Virus Infection in Colombia. N Engl J Med. 2016; 375(16):1513-1523. DOI: 10.1056/NEJMoa1605564. View

19.

Drumond B, Mondini A, Schmidt D, Bosch I, Nogueira M . Population dynamics of DENV-1 genotype V in Brazil is characterized by co-circulation and strain/lineage replacement. Arch Virol. 2012; 157(11):2061-73. DOI: 10.1007/s00705-012-1393-9. View

20.

SRIHONGSE S, Johnson C . The isolation of Ilhéus virus from man in Panamá. Am J Trop Med Hyg. 1967; 16(4):516-8. DOI: 10.4269/ajtmh.1967.16.516. View