Spontaneous Regeneration of the Mandible Following Hemimandibulectomy for Medication-related Osteonecrosis of the Jaw: A Case Report

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2020 Sep 3

PMID 32872069

Citations 2

Authors

Shinpei Matsuda

Hisato Yoshida

Minako Shimada

Hitoshi Yoshimura

Affiliations

Soon will be listed here.

Abstract

Rationale: Medication-related osteonecrosis of the jaw decreases quality of life of patients with cancer. The debate about it continues regarding the risk factors, etiology, and treatment methods, and so on. Also, spontaneous regeneration of the mandible is clinically rare.

Patient Concerns: A 67-year-old woman presented to the authors' department complaining of pain, swelling, and pus discharge from a fistula. She previously had breast cancer bone metastases and had received antiresorptive intravenous bisphosphonate.

Diagnosis: The patient was diagnosed with medication-related osteonecrosis of the jaw.

Interventions: She received conservative therapy with antibiotics and surgical therapy as sequestrectomy under general anesthesia; however, the lesion did not heal. Thirty months after the MRONJ diagnosis, when she was 70 years' old, she underwent a left hemimandibulectomy without reconstruction under general anesthesia.

Outcomes: Spontaneous regeneration of the mandible was observed by follow-up imaging examinations. The patient has no current subjective or objective symptoms.

Lessons: This is the first case report of the spontaneous mandibular regeneration after surgery for medication-related osteonecrosis of the jaw. Additionally, this case was the oldest patient among the published mandibular regeneration cases.

Citing Articles

Frutuoso F, Freitas F, Vilares M, Francisco H, Marques D, Carames J Diseases. 2024; 12(9).

PMID: 39329874 PMC: 11431443. DOI: 10.3390/diseases12090205.

An unusual case of bone regeneration of a necrotic mandible with pathologic fracture in an elderly hemodialysis patient with medication-related osteonecrosis of the jaw: a case report and review of the literature.

Yoshizawa K, Moroi A, Iguchi R, Takayama A, Goto J, Takayama Y J Med Case Rep. 2021; 15(1):608.

PMID: 34937568 PMC: 8697441. DOI: 10.1186/s13256-021-03206-5.

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