High Paip1 Expression As a Potential Prognostic Marker in Hepatocellular Carcinoma

Overview

Journal In Vivo

Specialty Oncology

Date 2020 Sep 3

PMID 32871777

Citations 6

Authors

Hayeon Kim

Wonkyung Jung

Aeree Kim

Han Kyeom Kim

Baek-Hui Kim

Affiliations

Soon will be listed here.

Abstract

Background/aim: Translation plays an important role in the carcinogenesis of various human tumors. Paip1 and eIF4A1 are translation-associated proteins that mediate the function of eukaryotic initiation factor 4F complex. This study aimed to analyse the relationship between the expression status of Paip1 and eIF4A1 and clinicopathologic features in hepatocellular carcinoma (HCC).

Materials And Methods: Immunohistochemical analysis was used to evaluate the expression status of Paip1 and eIF4A1. Two pathologists independently interpreted the immunostained slides. The prognostic value of Paip1 and eIF4A1 was evaluated by the Kaplan-Meier plotter.

Results: Among 173 HCC patients, 28 (16.1%) and 46 (26.6%) belonged in the Paip1 and eIF4A1 high-expression groups. High expression of Paip1 and eIF4A1 was associated with advanced TNM stage and more frequent vascular tumor invasion. Univariate analysis indicated that high Paip1 expression was associated with worse five-year overall survival (OS). Public dataset analysis by Kaplan-Meier plotter revealed that high mRNA expression of Paip1, and not of eIF4A1, was significantly associated with worse five-year OS and disease-free survival.

Conclusion: Paip1 expression has a potential prognostic value in human HCC.

Citing Articles

Ketogenic diet reshapes cancer metabolism through lysine β-hydroxybutyrylation.

Qin J, Huang X, Gou S, Zhang S, Gou Y, Zhang Q Nat Metab. 2024; 6(8):1505-1528.

PMID: 39134903 DOI: 10.1038/s42255-024-01093-w.

PAIP1 regulates expression of immune and inflammatory response associated genes at transcript level in liver cancer cell.

Zheng J, Fan W, Zhang X, Quan W, Wu Y, Shu M PeerJ. 2023; 11:e15070.

PMID: 37101794 PMC: 10124545. DOI: 10.7717/peerj.15070.

Human Proteome Microarray identifies autoantibodies to tumor-associated antigens as serological biomarkers for the diagnosis of hepatocellular carcinoma.

Yang Q, Ye H, Sun G, Wang K, Dai L, Qiu C Mol Oncol. 2023; 17(5):887-900.

PMID: 36587394 PMC: 10158779. DOI: 10.1002/1878-0261.13371.

Circ_0005576 Exerts an Oncogenic Role in Cervical Cancer via miR-1305-Dependent Regulation of PAIP1.

Wang Y, Du F, Xie Z, Lai J, Li Y, Xu Y Reprod Sci. 2022; 29(9):2647-2658.

PMID: 35378711 PMC: 9444835. DOI: 10.1007/s43032-022-00925-y.

Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma.

Swarup N, Hong K, Chawla K, Choi S, Shin J, Oh K Int J Oral Sci. 2022; 14(1):9.

PMID: 35153296 PMC: 8841500. DOI: 10.1038/s41368-022-00162-8.

References

Vaklavas C, Blume S, Grizzle W . Translational Dysregulation in Cancer: Molecular Insights and Potential Clinical Applications in Biomarker Development. Front Oncol. 2017; 7:158. PMC: 5526920. DOI: 10.3389/fonc.2017.00158. View

Guan H, Li N, Wang X, Shan X, Li Z, Lin Z . Role of Paip1 on angiogenesis and invasion in pancreatic cancer. Exp Cell Res. 2019; 376(2):198-209. DOI: 10.1016/j.yexcr.2019.01.017. View

Lino-Silva L, Gamboa-Dominguez A, Zuniga-Tamayo D, Lopez-Correa P . Interobserver variability in colorectal cancer and the 2016 ITBCC concensus. Mod Pathol. 2018; 32(1):159-160. DOI: 10.1038/s41379-018-0027-5. View

Spilka R, Ernst C, Mehta A, Haybaeck J . Eukaryotic translation initiation factors in cancer development and progression. Cancer Lett. 2013; 340(1):9-21. DOI: 10.1016/j.canlet.2013.06.019. View

EDMONDSON H, STEINER P . Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 1954; 7(3):462-503. DOI: 10.1002/1097-0142(195405)7:3<462::aid-cncr2820070308>3.0.co;2-e. View

Li W, Chen A, Xiong L, Chen T, Tao F, Lu Y . miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1. Tumour Biol. 2017; 39(5):1010428317698389. DOI: 10.1177/1010428317698389. View

Cao W, Wei W, Zhan Z, Xie Y, Xiao Q . MiR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1. Oncol Rep. 2016; 35(5):2583-91. DOI: 10.3892/or.2016.4643. View

Wang Q, Han A, Chen L, Sun J, Lin Z, Zhang X . Paip1 overexpression is involved in the progression of gastric cancer and predicts shorter survival of diagnosed patients. Onco Targets Ther. 2019; 12:6565-6576. PMC: 6701649. DOI: 10.2147/OTT.S202698. View

Aleskandarany M, Sonbul S, Mukherjee A, Rakha E . Molecular Mechanisms Underlying Lymphovascular Invasion in Invasive Breast Cancer. Pathobiology. 2015; 82(3-4):113-23. DOI: 10.1159/000433583. View

10.

Roy G, De Crescenzo G, Khaleghpour K, Kahvejian A, OConnor-Mccourt M, Sonenberg N . Paip1 interacts with poly(A) binding protein through two independent binding motifs. Mol Cell Biol. 2002; 22(11):3769-82. PMC: 133836. DOI: 10.1128/MCB.22.11.3769-3782.2002. View

11.

Wei W, Cao W, Zhan Z, Yan L, Xie Y, Xiao Q . MiR-1284 suppresses gastric cancer progression by targeting EIF4A1. Onco Targets Ther. 2019; 12:3965-3976. PMC: 6535428. DOI: 10.2147/OTT.S191015. View

12.

Sonenberg N, Hinnebusch A . Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell. 2009; 136(4):731-45. PMC: 3610329. DOI: 10.1016/j.cell.2009.01.042. View

13.

Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J . eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nat Commun. 2019; 10(1):5151. PMC: 6853918. DOI: 10.1038/s41467-019-13086-5. View

14.

Wang Y, Piao J, Wang Q, Cui X, Meng Z, Jin T . Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma. Hum Pathol. 2018; 86:233-242. DOI: 10.1016/j.humpath.2018.11.017. View

15.

Pelletier J, Graff J, Ruggero D, Sonenberg N . Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. Cancer Res. 2015; 75(2):250-63. PMC: 4299928. DOI: 10.1158/0008-5472.CAN-14-2789. View

16.

Piao J, Chen L, Jin T, Xu M, Quan C, Lin Z . Paip1 affects breast cancer cell growth and represents a novel prognostic biomarker. Hum Pathol. 2017; 73:33-40. DOI: 10.1016/j.humpath.2017.10.037. View

17.

Craig A, Haghighat A, Yu A, Sonenberg N . Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature. 1998; 392(6675):520-3. DOI: 10.1038/33198. View