The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Sep 2

PMID 32867386

Citations 10

Authors

Ismael Khouly

Rosalie Salus Braun

Michelle Ordway

Bradley Eric Aouizerat

Iya Ghassib

Lena Larsson

Farah Asaad

Affiliations

Soon will be listed here.

Abstract

Despite a number of reports in the literature on the role of epigenetic mechanisms in periodontal disease, a thorough assessment of the published studies is warranted to better comprehend the evidence on the relationship between epigenetic changes and periodontal disease and its treatment. Therefore, the aim of this systematic review is to identify and synthesize the evidence for an association between DNA methylation/histone modification and periodontal disease and its treatment in human adults. A systematic search was independently conducted to identify articles meeting the inclusion criteria. DNA methylation and histone modifications associated with periodontal diseases, gene expression, epigenetic changes after periodontal therapy, and the association between epigenetics and clinical parameters were evaluated. Sixteen studies were identified. All included studies examined DNA modifications in relation to periodontitis, and none of the studies examined histone modifications. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology, was found. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal disease. , , , , , and were identified as candidate genes that have been assessed for DNA methylation in periodontitis. While several included studies found associations between methylation levels and periodontal disease risk, there is insufficient evidence to support or refute an association between DNA methylation and periodontal disease/therapy in human adults. Further research must be conducted to identify reproducible epigenetic markers and determine the extent to which DNA methylation can be applied as a clinical biomarker.

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References

Kobayashi T, Ishida K, Yoshie H . Increased expression of interleukin-6 (IL-6) gene transcript in relation to IL-6 promoter hypomethylation in gingival tissue from patients with chronic periodontitis. Arch Oral Biol. 2016; 69:89-94. DOI: 10.1016/j.archoralbio.2016.05.018. View

Hernandez M, Martinez B, Tejerina J, Valenzuela M, Gamonal J . MMP-13 and TIMP-1 determinations in progressive chronic periodontitis. J Clin Periodontol. 2007; 34(9):729-35. DOI: 10.1111/j.1600-051X.2007.01107.x. View

de Faria Amormino S, Arao T, Saraiva A, Gomez R, Dutra W, da Costa J . Hypermethylation and low transcription of TLR2 gene in chronic periodontitis. Hum Immunol. 2013; 74(9):1231-6. DOI: 10.1016/j.humimm.2013.04.037. View

Page R, Kornman K . The pathogenesis of human periodontitis: an introduction. Periodontol 2000. 1997; 14:9-11. DOI: 10.1111/j.1600-0757.1997.tb00189.x. View

Viana M, Cardoso F, Diniz M, Costa F, da Costa J, Gomez R . Methylation pattern of IFN-γ and IL-10 genes in periodontal tissues. Immunobiology. 2011; 216(8):936-41. DOI: 10.1016/j.imbio.2011.01.006. View

Mitani A, Niedbala W, Fujimura T, Mogi M, Miyamae S, Higuchi N . Increased expression of interleukin (IL)-35 and IL-17, but not IL-27, in gingival tissues with chronic periodontitis. J Periodontol. 2014; 86(2):301-9. DOI: 10.1902/jop.2014.140293. View

Andia D, De Oliveira N, Casarin R, Casati M, Line S, de Souza A . DNA methylation status of the IL8 gene promoter in aggressive periodontitis. J Periodontol. 2010; 81(9):1336-41. DOI: 10.1902/jop.2010.100082. View

Borrell L, Papapanou P . Analytical epidemiology of periodontitis. J Clin Periodontol. 2005; 32 Suppl 6:132-58. DOI: 10.1111/j.1600-051X.2005.00799.x. View

Takeichi O, Haber J, Kawai T, Smith D, Moro I, Taubman M . Cytokine profiles of T-lymphocytes from gingival tissues with pathological pocketing. J Dent Res. 2000; 79(8):1548-55. DOI: 10.1177/00220345000790080401. View

10.

Duarte P, Da Rocha M, Sampaio E, Mestnik M, Feres M, Figueiredo L . Serum levels of cytokines in subjects with generalized chronic and aggressive periodontitis before and after non-surgical periodontal therapy: a pilot study. J Periodontol. 2010; 81(7):1056-63. DOI: 10.1902/jop.2010.090732. View

11.

Zhang Q, Chen B, Yan F, Guo J, Zhu X, Ma S . Interleukin-10 inhibits bone resorption: a potential therapeutic strategy in periodontitis and other bone loss diseases. Biomed Res Int. 2014; 2014:284836. PMC: 3947664. DOI: 10.1155/2014/284836. View

12.

Beklen A, Sorsa T, Konttinen Y . Toll-like receptors 2 and 5 in human gingival epithelial cells co-operate with T-cell cytokine interleukin-17. Oral Microbiol Immunol. 2009; 24(1):38-42. DOI: 10.1111/j.1399-302X.2008.00473.x. View

13.

Finoti L, Nepomuceno R, Pigossi S, Corbi S, Secolin R, Scarel-Caminaga R . Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore). 2017; 96(22):e6932. PMC: 5459707. DOI: 10.1097/MD.0000000000006932. View

14.

Li X, Lu J, Teng W, Zhao C, Ye X . Quantitative Evaluation of MMP-9 and TIMP-1 Promoter Methylation in Chronic Periodontitis. DNA Cell Biol. 2018; 37(3):168-173. DOI: 10.1089/dna.2017.3948. View

15.

Cekici A, Kantarci A, Hasturk H, Van Dyke T . Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000. 2013; 64(1):57-80. PMC: 4500791. DOI: 10.1111/prd.12002. View

16.

Baptista N, Portinho D, Casarin R, Vale H, Casati M, de Souza A . DNA methylation levels of SOCS1 and LINE-1 in oral epithelial cells from aggressive periodontitis patients. Arch Oral Biol. 2014; 59(7):670-8. DOI: 10.1016/j.archoralbio.2014.03.015. View

17.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

18.

Su H, Gornitsky M, Velly A, Yu H, Benarroch M, Schipper H . Salivary DNA, lipid, and protein oxidation in nonsmokers with periodontal disease. Free Radic Biol Med. 2009; 46(7):914-21. DOI: 10.1016/j.freeradbiomed.2009.01.008. View

19.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009; 6(7):e1000100. PMC: 2707010. DOI: 10.1371/journal.pmed.1000100. View

20.

Shaddox L, Mullersman A, Huang H, Wallet S, Langaee T, Aukhil I . Epigenetic regulation of inflammation in localized aggressive periodontitis. Clin Epigenetics. 2017; 9:94. PMC: 5581417. DOI: 10.1186/s13148-017-0385-8. View