Central Odontogenic Fibroma with the Presence of Large Fibroblasts of Varying Morphology

Overview

Journal Head Neck Pathol

Specialties Oncology
Pathology

Date 2020 Sep 1

PMID 32865727

Citations 1

Authors

Victor Costa

Ana Lia Anbinder

Fernanda Herrera

Nayara Rodrigues

Ana Sueli Rodrigues Cavalcante

Estela Kaminagakura

Affiliations

Soon will be listed here.

Abstract

A patient with an odontogenic fibroma (OF) with the presence of fibroblasts of varying morphology is presented, and the main microscopic differential diagnosis is discussed. Case report: a 51-year-old man complained of a swelling in the anterior region of the mandible. The panoramic radiograph showed a radiolucent, well-defined multilocular image, with displacement of the roots of the left mandibular incisors and canine. A cone beam computed tomography examination revealed a hypodense image, with delicate bone spicules inside, divergence of the tooth roots and destruction of the buccal cortical bone. Under the differential diagnosis of a desmoplastic ameloblastoma or a squamous odontogenic tumor, an incisional biopsy was made. Microscopically, deeply collagenized tissue with scarce odontogenic epithelium islands, large fibroblasts of varying morphology and calcified material was observed. A diagnosis of OF was made. Surgical removal was carried out, and the specimen was examined. Identical aspects were found, and the immunohistochemical reaction for pan-cytokeratin was carried out to identify the odontogenic epithelial cells. The definitive diagnosis of OF was confirmed, and we emphasize the importance of the correlation of all characteristics for a definitive diagnosis.

Citing Articles

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Hande A, Kalmegh P, Sonone A, Patil S, Sharma P, Pakhale A Cureus. 2024; 16(4):e58154.

PMID: 38741876 PMC: 11089489. DOI: 10.7759/cureus.58154.

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