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The Role of the Immune System During Regeneration of the Central Nervous System

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Date 2020 Sep 1
PMID 32864529
Citations 4
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Abstract

Central nervous system damage in mammals leads to neuronal cell death, axonal degeneration, and formation of a glial scar resulting in functional and behavioral defects. Other vertebrates, like fish and salamanders, have retained the ability to functionally regenerate after central nervous system injury. To date research from many research organisms has led to a more concise understanding of the response of local neural cells to injury. However, it has become clear that non-neural cells of the immune system play an important role in determining the tissue response to injury. In this review we briefly consider the mammalian response to injury compared to organisms with the natural ability to regenerate. We then discuss similarities and differences in how cells of the innate and adaptive immune system respond and contribute to tissue repair in various species.

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References
1.
Jin L, Zhang G, Jamison Jr C, Takano H, Haydon P, Selzer M . Axon regeneration in the absence of growth cones: acceleration by cyclic AMP. J Comp Neurol. 2009; 515(3):295-312. DOI: 10.1002/cne.22057. View

2.
Jameson J, Ugarte K, Chen N, Yachi P, Fuchs E, Boismenu R . A role for skin gammadelta T cells in wound repair. Science. 2002; 296(5568):747-9. DOI: 10.1126/science.1069639. View

3.
Sharir R, Semo J, Shimoni S, Ben-Mordechai T, Landa-Rouben N, Maysel-Auslender S . Experimental myocardial infarction induces altered regulatory T cell hemostasis, and adoptive transfer attenuates subsequent remodeling. PLoS One. 2014; 9(12):e113653. PMC: 4249913. DOI: 10.1371/journal.pone.0113653. View

4.
Wang X, Cao K, Sun X, Chen Y, Duan Z, Sun L . Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris. Glia. 2014; 63(4):635-51. PMC: 4331228. DOI: 10.1002/glia.22774. View

5.
de Castro Jr R, Hughes M, Xu G, Clifton C, Calingasan N, Gelman B . Evidence that infiltrating neutrophils do not release reactive oxygen species in the site of spinal cord injury. Exp Neurol. 2004; 190(2):414-24. DOI: 10.1016/j.expneurol.2004.05.046. View