Synthesis of MeBmt and Related Derivatives Syn-selective ATH-DKR

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2020 Sep 1

PMID 32864110

Citations 4

Authors

Adam Rolt

Paul M ONeill

T Jake Liang

Andrew V Stachulski

Affiliations

Soon will be listed here.

Abstract

The unusual α-amino, β-hydroxy acid MeBmt is a key structural feature of cyclosporin A, an important naturally occurring immunosuppressant and antiviral agent. We present a convergent synthesis of MeBmt which relies on new aspects of dynamic kinetic resolution (DKR) to establish simultaneously the chirality at C(2) and C(3). We also show that this route is applicable to the synthesis of other derivatives.

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