Metabolic and Clinical Responses to Bunium Persicum (black Caraway) Supplementation in Overweight and Obese Patients with Type 2 Diabetes: a Double-blind, Randomized Placebo-controlled Clinical Trial

Overview

Journal Nutr Metab (Lond)

Publisher Biomed Central

Date 2020 Sep 1

PMID 32863846

Citations 3

Authors

Saber Jafari-Maskouni

Mansour Shahraki

Milad Daneshi-Maskooni

Alireza Dashipour

Ali Shamsi-Goushki

Zinat Mortazavi

Affiliations

Soon will be listed here.

Abstract

Background: Diabetes mellitus is the most common metabolic disorder worldwide. We aimed to determine the metabolic and clinical responses to Bunium Persicum (Black Caraway) supplementation in overweight and obese patients with T2DM.

Methods: Participant recruitment took place in the diabetic clinic of Bu-Ali hospital in Zahedan. Due to the eligibility criteria, 60 participants were randomly placed into two groups, namely placebo ( = 30) and BP ( = 30). The supplementation was considered one 1000 mg capsule 2 times /day BP by meals (lunch and dinner) for 8 weeks. Physical activity levels, dietary intakes, anthropometric measurements [weight, height, and waist circumference], glycemic indices [fasting blood glucose (FBG) and insulin (FBI)], blood lipids [triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c)], and serum nesfatin-1 level were determined. Homeostasis model assessment-insulin resistance (HOMA-IR), Quantitative insulin sensitivity checks index (QUICKI), and Body Mass Index (BMI) were computed.

Results: In comparison with placebo, BP significantly decreased FBG, HOMA-IR, and BMI (). The differences in the FBI, QUICKI, TG, TC, LDL, HDL, WC, and Nesfatin-1 were not significant ().

Conclusion: BP supplementation improved serum glucose indices and BMI among overweight and obese T2DM patients. Further trials are needed to confirm results.

Trial Registration: Iranian Registry of Clinical Trials (IRCT), IRCT20181207041876N1, Registered 18/01/2019, https://irct.ir/trial/35752.

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References

Tsuchiya T, Shimizu H, Yamada M, Osaki A, Oh-I S, Ariyama Y . Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males. Clin Endocrinol (Oxf). 2010; 73(4):484-90. DOI: 10.1111/j.1365-2265.2010.03835.x. View

Ozturk Ozkan G . Effects of Nesfatin-1 on Food Intake and Hyperglycemia. J Am Coll Nutr. 2019; 39(4):345-351. DOI: 10.1080/07315724.2019.1646678. View

Sharififar F, Yassa N, Mozaffarian V . Bioactivity of major components from the seeds of Bunium persicum (Boiss.) Fedtch. Pak J Pharm Sci. 2010; 23(3):300-4. View

Lovic D, Piperidou A, Zografou I, Grassos H, Pittaras A, Manolis A . The Growing Epidemic of Diabetes Mellitus. Curr Vasc Pharmacol. 2019; 18(2):104-109. DOI: 10.2174/1570161117666190405165911. View

Giancarlo S, Rosa L, Nadjafi F, Francesco M . Hypoglycaemic activity of two spices extracts: Rhus coriaria L. and Bunium persicum Boiss. Nat Prod Res. 2006; 20(9):882-6. DOI: 10.1080/14786410500520186. View

Li Q, Wang H, Chen X, Guan H, Jiang Z . Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans. Regul Pept. 2009; 159(1-3):72-7. DOI: 10.1016/j.regpep.2009.11.003. View

Smitka K, Maresova D . Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment. Prague Med Rep. 2015; 116(2):87-111. DOI: 10.14712/23362936.2015.49. View

Khorchani M, Zal F, Neisy A . The phytoestrogen, quercetin, in serum, uterus and ovary as a potential treatment for dehydroepiandrosterone-induced polycystic ovary syndrome in the rat. Reprod Fertil Dev. 2019; 32(3):313-321. DOI: 10.1071/RD19072. View

Kazemipoor M, Hamzah S, Hajifaraji M, Wan Mohamed Radzi C, Cordell G . Slimming and Appetite-Suppressing Effects of Caraway Aqueous Extract as a Natural Therapy in Physically Active Women. Phytother Res. 2016; 30(6):981-7. DOI: 10.1002/ptr.5603. View

10.

Haque M, Ansari H . Anti-Obesity Effect of Arq Zeera and Its Main Components Thymol and Cuminaldehyde in High Fat Diet Induced Obese Rats. Drug Res (Stuttg). 2018; 68(11):637-647. DOI: 10.1055/a-0590-1956. View

11.

Seri A, Khorsand M, Rezaei Z, Hamedi A, Takhshid M . Inhibitory Effect of Bunium Persicum Hydroalcoholic Extract on Glucose-Induced Albumin Glycation, Oxidation, and Aggregation In Vitro. Iran J Med Sci. 2017; 42(4):369-376. PMC: 5523044. View

12.

Gonzalez R, Kerbel B, Chun A, Unniappan S . Molecular, cellular and physiological evidences for the anorexigenic actions of nesfatin-1 in goldfish. PLoS One. 2010; 5(12):e15201. PMC: 2997068. DOI: 10.1371/journal.pone.0015201. View

13.

Patil S, Takalikar S, Joglekar M, Haldavnekar V, Arvindekar A . Insulinotropic and β-cell protective action of cuminaldehyde, cuminol and an inhibitor isolated from Cuminum cyminum in streptozotocin-induced diabetic rats. Br J Nutr. 2013; 110(8):1434-43. DOI: 10.1017/S0007114513000627. View

14.

Garcia-Galiano D, Pineda R, Ilhan T, Castellano J, Ruiz-Pino F, Sanchez-Garrido M . Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis. Endocrinology. 2012; 153(4):1959-71. DOI: 10.1210/en.2011-2032. View

15.

Kazemipoor M, Wan Mohamed Radzi C, Hajifaraji M, Haerian B, Mosaddegh M, Cordell G . Antiobesity effect of caraway extract on overweight and obese women: a randomized, triple-blind, placebo-controlled clinical trial. Evid Based Complement Alternat Med. 2013; 2013:928582. PMC: 3844184. DOI: 10.1155/2013/928582. View

16.

Mirzaei K, Hossein-Nezhad A, Keshavarz S, Koohdani F, Eshraghian M, Saboor-Yaraghi A . Association of nesfatin-1 level with body composition, dietary intake and resting metabolic rate in obese and morbid obese subjects. Diabetes Metab Syndr. 2014; 9(4):292-8. DOI: 10.1016/j.dsx.2014.04.010. View

17.

Shimizu H, Oh-I S, Okada S, Mori M . Nesfatin-1: an overview and future clinical application. Endocr J. 2009; 56(4):537-43. DOI: 10.1507/endocrj.k09e-117. View

18.

Hajhashemi V, Sajjadi S, Zomorodkia M . Antinociceptive and anti-inflammatory activities of Bunium persicum essential oil, hydroalcoholic and polyphenolic extracts in animal models. Pharm Biol. 2010; 49(2):146-51. DOI: 10.3109/13880209.2010.504966. View

19.

Jabbari M, Daneshfard B, Emtiazy M, Khiveh A, Hashempur M . Biological Effects and Clinical Applications of Dwarf Elder ( Sambucus ebulus L): A Review. J Evid Based Complementary Altern Med. 2017; 22(4):996-1001. PMC: 5871274. DOI: 10.1177/2156587217701322. View

20.

Nickavar B, Adeli A, Nickavar A . Analyses of the essential oil from Bunium persicum fruit and its antioxidant constituents. J Oleo Sci. 2014; 63(7):741-6. DOI: 10.5650/jos.ess13168. View