Application of a Quartz Crystal Microbalance to Measure the Mass Concentration of Combustion Particle Suspensions
Overview
Authors
Affiliations
Researchers studying the biological effects of combustion particles typically rely on suspending particles in de-ionized (DI) water, buffer, and/or media prior to in vitro or in vivo experiments. However, the hydrophobic nature of combustion particles makes it difficult to obtain well-suspended, evenly dispersed mixtures, which also makes it difficult to obtain equivalent dosing and endpoint comparisons. This study explored the use of a quartz crystal microbalance (QCM) to measure the mass concentration of combustion particle suspensions. It compared the QCM mass concentration to that estimated by placing a known mass of combustion particles in DI water. It also evaluated the effect of drop volume and combustion particle type on QCM measurements. The results showed that QCM is a promising direct method for measuring suspended combustion particle mass concentrations, and it is particularly effective for quantifying concentrations of difficult-to-suspend particles and for combustion particles placed in polystyrene containers, which can lead to substantial particle losses.
Miller-Holt J, Behrsing H, Crooks I, Curren R, Demir K, Gafner J Drug Test Anal. 2022; 15(10):1175-1188.
PMID: 35830202 PMC: 9897201. DOI: 10.1002/dta.3344.
Kaur K, Mohammadpour R, Sturrock A, Ghandehari H, Reilly C, Paine 3rd R J Environ Sci Health A Tox Hazard Subst Environ Eng. 2022; 57(7):540-551.
PMID: 35722658 PMC: 9354920. DOI: 10.1080/10934529.2022.2083429.
Kaur K, Overacker D, Ghandehari H, Reilly C, Paine 3rd R, Kelly K J Aerosol Sci. 2020; 151.
PMID: 33012843 PMC: 7529104. DOI: 10.1016/j.jaerosci.2020.105653.
Ding Y, Weindl P, Lenz A, Mayer P, Krebs T, Schmid O Part Fibre Toxicol. 2020; 17(1):44.
PMID: 32938469 PMC: 7493184. DOI: 10.1186/s12989-020-00376-w.