Multivalent Weak Interactions Enhance Selectivity of Interparticle Binding

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2020 Aug 30

PMID 32859760

Citations 19

Authors

M R W Scheepers

L J van IJzendoorn

M W J Prins

Affiliations

Soon will be listed here.

Abstract

Targeted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal particles. Extensive theoretical work has shown that two factors are necessary to achieve high selectivity for a threshold receptor density: multivalency and weak interactions. Here, we study a model system of DNA-coated particles with multivalent and weak interactions that mimics ligand-receptor interactions between particles and cells. Using an optomagnetic cluster experiment, particle aggregation rates are measured as a function of ligand and receptor densities. The measured aggregation rates show that the binding becomes more selective for shorter DNA ligand-receptor pairs, proving that multivalent weak interactions lead to enhanced selectivity in interparticle binding. Simulations confirm the experimental findings and show the role of ligand-receptor dissociation in the selectivity of the weak multivalent binding.

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