Polymorphisms of Brain-derived Neurotrophic Factor Genes Are Associated with Anxiety and Body Mass Index in Fibromyalgia Syndrome Patients

Overview

Journal BMC Res Notes

Publisher Biomed Central

Specialties Biology
General Medicine

Date 2020 Aug 30

PMID 32859253

Citations 5

Authors

Boya Nugraha

Sumadi Lukman Anwar

Christoph Gutenbrunner

Christoph Korallus

Affiliations

Soon will be listed here.

Abstract

Objective: Fibromyalgia syndrome has been associated with familial clusters although the specific genetic predisposition is not clear. Accordingly, studies concerning genetic factors associated with this disease are important. Brain-derived neurotrophic factor (BDNF) has been shown to play a role in patients with fibromyalgia syndrome, particularly in mediating manifestations of pain and mood-related symptoms. Research on genetic factors, including genetic variations or single nucleotide polymorphisms, especially related to BDNF in fibromyalgia is very limited. Therefore, this study was aiming at determining the association of polymorphisms of BDNF, particularly rs2049046 (A>T) and rs7124442 (A>G), with body mass index (BMI) and mood-related symptoms in FMS.

Results: In fibromyalgia syndrome cases, BDNF polymorphisms were associated with body mass index and anxiety score, specifically rs7124442 (A>G) (Fisher's exact test χ; p < 0.05; odds ratio (OR): 1.02) and rs2049046 (A>T) (Fisher's exact test χ; p < 0.05; OR: 0.55), respectively. Additionally, patients with fibromyalgia syndrome who have AA (95% CI (8.71, 11.63)) and AT (95% CI (9.32, 11.74)) alleles of rs2049046 showed higher score of anxiety compared to patients with TT (95% CI (3.98, 8.20) allele (ANOVA test; p < 0.01). These results suggest that BDNF polymorphisms (rs7124442 and rs2049046) are associated with body mass index and anxiety symptoms in patients with fibromyalgia syndrome.

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References

Haas L, Portela L, Bohmer A, Oses J, Lara D . Increased plasma levels of brain derived neurotrophic factor (BDNF) in patients with fibromyalgia. Neurochem Res. 2010; 35(5):830-4. DOI: 10.1007/s11064-010-0129-z. View

Lemos C, Mendonca D, Pereira-Monteiro J, Barros J, Sequeiros J, Alonso I . BDNF and CGRP interaction: implications in migraine susceptibility. Cephalalgia. 2010; 30(11):1375-82. DOI: 10.1177/0333102410368443. View

Akbarian S, Salehi-Abargouei A, Pourmasoumi M, Kelishadi R, Nikpour P, Heidari-Beni M . Association of Brain-derived neurotrophic factor gene polymorphisms with body mass index: A systematic review and meta-analysis. Adv Med Sci. 2017; 63(1):43-56. DOI: 10.1016/j.advms.2017.07.002. View

Hawker G, Mian S, Kendzerska T, French M . Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain.... Arthritis Care Res (Hoboken). 2012; 63 Suppl 11:S240-52. DOI: 10.1002/acr.20543. View

Gatt J, Nemeroff C, Dobson-Stone C, Paul R, Bryant R, Schofield P . Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Mol Psychiatry. 2009; 14(7):681-95. DOI: 10.1038/mp.2008.143. View

Mercader J, Fernandez-Aranda F, Gratacos M, Ribases M, Badia A, Villarejo C . Blood levels of brain-derived neurotrophic factor correlate with several psychopathological symptoms in anorexia nervosa patients. Neuropsychobiology. 2008; 56(4):185-90. DOI: 10.1159/000120623. View

Chen Z, Patel P, Sant G, Meng C, Teng K, Hempstead B . Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci. 2004; 24(18):4401-11. PMC: 6729450. DOI: 10.1523/JNEUROSCI.0348-04.2004. View

Sutherland H, Maher B, Rodriguez-Acevedo A, Haupt L, Griffiths L . Investigation of brain-derived neurotrophic factor (BDNF) gene variants in migraine. Headache. 2014; 54(7):1184-93. DOI: 10.1111/head.12351. View

Buskila D, Sarzi-Puttini P . Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome. Arthritis Res Ther. 2006; 8(5):218. PMC: 1779444. DOI: 10.1186/ar2005. View

10.

Casas E, Garcia M, Wells J, Smith T . Association of single nucleotide polymorphisms in the ANKRA2 and CD180 genes with bovine respiratory disease and presence of Mycobacterium avium subsp. paratuberculosis(1). Anim Genet. 2011; 42(6):571-7. DOI: 10.1111/j.1365-2052.2011.02189.x. View

11.

Bonaccorso S, Sodhi M, Li J, Bobo W, Chen Y, Tumuklu M . The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia. Bipolar Disord. 2015; 17(5):528-35. DOI: 10.1111/bdi.12294. View

12.

Matsuda J, Barbosa F, Morel L, de Castro Franca S, Zingaretti S, Silva L . Serotonin receptor (5-HT 2A) and catechol-O-methyltransferase (COMT) gene polymorphisms: triggers of fibromyalgia?. Rev Bras Reumatol. 2010; 50(2):141-9. View

13.

Nugraha B, Korallus C, Gutenbrunner C . Serum level of brain-derived neurotrophic factor in fibromyalgia syndrome correlates with depression but not anxiety. Neurochem Int. 2013; 62(3):281-6. DOI: 10.1016/j.neuint.2013.01.001. View

14.

Schule C, Zill P, Baghai T, Eser D, Zwanzger P, Wenig N . Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients. Psychoneuroendocrinology. 2006; 31(8):1019-25. DOI: 10.1016/j.psyneuen.2006.06.002. View

15.

Zhang C, Chen Y, Chen W . Association of psychosocial factors with anxiety and depressive symptoms in Chinese patients with type 2 diabetes. Diabetes Res Clin Pract. 2007; 79(3):523-30. DOI: 10.1016/j.diabres.2007.10.014. View

16.

Fietta P, Fietta P, Manganelli P . Fibromyalgia and psychiatric disorders. Acta Biomed. 2007; 78(2):88-95. View

17.

Sarchielli P, Mancini M, Floridi A, Coppola F, Rossi C, Nardi K . Increased levels of neurotrophins are not specific for chronic migraine: evidence from primary fibromyalgia syndrome. J Pain. 2007; 8(9):737-45. DOI: 10.1016/j.jpain.2007.05.002. View

18.

Melchers I, Blaschke S, Hecker M, Cattaruzza M . The -786C/T single-nucleotide polymorphism in the promoter of the gene for endothelial nitric oxide synthase: insensitivity to physiologic stimuli as a risk factor for rheumatoid arthritis. Arthritis Rheum. 2006; 54(10):3144-51. DOI: 10.1002/art.22147. View

19.

Schumacher J, Abou Jamra R, Becker T, Ohlraun S, Klopp N, Binder E . Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry. 2005; 58(4):307-14. DOI: 10.1016/j.biopsych.2005.04.006. View

20.

Wolfe F, Smythe H, Yunus M, Bennett R, Bombardier C, Goldenberg D . The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990; 33(2):160-72. DOI: 10.1002/art.1780330203. View