Recent Advances in Asymmetric Iron Catalysis

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Aug 30

PMID 32858925

Citations 10

Authors

Alessandra Casnati

Matteo Lanzi

Gianpiero Cera

Affiliations

Soon will be listed here.

Abstract

Asymmetric transition-metal catalysis represents a fascinating challenge in the field of organic chemistry research. Since seminal advances in the late 60s, which were finally recognized by the Nobel Prize to Noyori, Sharpless and Knowles in 2001, the scientific community explored several approaches to emulate nature in producing chiral organic molecules. In a scenario that has been for a long time dominated by the use of late-transition metals (TM) catalysts, the use of 3d-TMs and particularly iron has found, recently, a widespread application. Indeed, the low toxicity and the earth-abundancy of iron, along with its chemical versatility, allowed for the development of unprecedented and more sustainable catalytic transformations. While several competent reviews tried to provide a complete picture of the astounding advances achieved in this area, within this review we aimed to survey the latest achievements and new concepts brought in the field of enantioselective iron-catalyzed transformations.

Citing Articles

β-Tryptophans by Iron-Catalyzed Enantioselective Amination of 3-Indolepropionic Acids.

Zhou B, Ih M, Yao S, Hemming M, Ivlev S, Chen S Org Lett. 2024; 26(39):8361-8365.

PMID: 39311759 PMC: 11459507. DOI: 10.1021/acs.orglett.4c03130.

Stereogenic-at-iron mesoionic carbene complex for enantioselective C-H amidation.

Demirel N, Dawor M, Nadler G, Ivlev S, Meggers E Chem Sci. 2024; .

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Mild Iron-Catalyzed Oxidative Cross-Coupling of Quinoxalinones with Indoles.

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Iron-catalyzed stereoselective C-H alkylation for simultaneous construction of C-N axial and C-central chirality.

Zhang Z, Jacob N, Bhatia S, Boos P, Chen X, DeMuth J Nat Commun. 2024; 15(1):3503.

PMID: 38664372 PMC: 11045758. DOI: 10.1038/s41467-024-47589-7.

Insight into Radical Initiation, Solvent Effects, and Biphenyl Production in Iron-Bisphosphine Cross-Couplings.

Aguilera M, Gogoi A, Lee W, Liu L, Brennessel W, Gutierrez O ACS Catal. 2023; 13(13):8987-8996.

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