Saturated Fatty Acid-Based In Situ Forming Matrices for Localized Antimicrobial Delivery

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2020 Aug 29

PMID 32854439

Citations 11

Authors

Takron Chantadee

Wichai Santimaleeworagun

Yaowaruk Phorom

Thawatchai Phaechamud

Affiliations

Soon will be listed here.

Abstract

In recent years, the world has faced the issue of antibiotic resistance. Methicillin-resistant (MRSA) is a significant problem in various treatments and control of infections. Biocompatible materials with saturated fatty acids of different chain lengths (C-C) were studied as matrix formers of localized injectable vancomycin HCl (VCM)-loaded antisolvent-induced in situ forming matrices. The series of fatty acid-based in situ forming matrices showed a low viscosity (5.47-13.97 cPs) and pH value in the range of 5.16-6.78, with high injectability through a 27-G needle (1.55-3.12 N). The preparations exhibited low tolerance to high concentrations of KHPO solution (1.88-5.42% ) and depicted an electrical potential change during phase transformation. Their phase transition and matrix formation at the microscopic and macroscopic levels depended on the chain length of fatty acids and solvent characteristics. The VCM release pattern depended on the nucleation/crystallization and solvent exchange behaviors of the delivery system. The 35% of C-C fatty acid-based in situ forming matrix prolonged the VCM release over seven days in which C, C, C -based formulation reached 56, 84, and 85% cumulative drug release at 7 day. The release data fitted well with Higuchi's model. The developed formulations presented efficient antimicrobial activities against standard , MRSA, , and . Hence, VCM-loaded antisolvent-induced fatty acid-based in situ forming matrix is a potential local delivery system for the treatment of local Gram-positive infection sites, such as joints, eyes, dermis of surgery sites, etc., in the future.

Citing Articles

Cellulose Acetate Butyrate-Based In Situ Gel Comprising Doxycycline Hyclate and Metronidazole.

Khaing E, Lertsuphotvanit N, Thammasut W, Rojviriya C, Chansatidkosol S, Phattarateera S Polymers (Basel). 2025; 16(24.

PMID: 39771329 PMC: 11728690. DOI: 10.3390/polym16243477.

Fluconazole-Loaded Ibuprofen In Situ Gel-Based Oral Spray for Oropharyngeal Candidiasis Treatment.

Khaing E, Senarat S, Jitrangsri K, Phaechamud T AAPS PharmSciTech. 2024; 25(5):89.

PMID: 38641711 DOI: 10.1208/s12249-024-02804-y.

Injectable Gamboge-Based In Situ Gel for Sustained Delivery of Imatinib Mesylate.

Jitrangsri K, Khaing E, Intaraphairot T, Phaechamud T, Mahadlek J Gels. 2023; 9(9).

PMID: 37754418 PMC: 10529659. DOI: 10.3390/gels9090737.

Ways to Assess and Regulate the Performance of a Bi-Mechanism-Induced Borneol-Based In Situ Forming Matrix.

Lertsuphotvanit N, Sirirak J, Tamdee P, Tuntarawongsa S, Phaechamud T, Chantadee T Pharmaceutics. 2023; 15(8).

PMID: 37631268 PMC: 10459226. DOI: 10.3390/pharmaceutics15082053.

Phase Inversion-Based Doxycycline Hyclate-Incorporated Borneol In Situ Gel for Periodontitis Treatment.

Lertsuphotvanit N, Tuntarawongsa S, Chantadee T, Phaechamud T Gels. 2023; 9(7).

PMID: 37504434 PMC: 10380060. DOI: 10.3390/gels9070557.

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