A Simple Predictive Model for Estimating Relative E-cigarette Toxic Carbonyl Levels

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2020 Aug 27

PMID 32845911

Citations 5

Authors

Shawna Vreeke

Xijing Zhu

Robert M Strongin

Affiliations

Soon will be listed here.

Abstract

E-cigarette devices are wide ranging, leading to significant differences in levels of toxic carbonyls in their respective aerosols. Power can be a useful method in predicting relative toxin concentrations within the same device, but does not correlate well to inter-device levels. Herein, we have developed a simple mathematical model utilizing parameters of an e-cigarette's coil and wick in order to predict relative levels of e-liquid solvent degradation. Model 1, which is coil length/(wick surface area*wraps), performed in the moderate-to-substantial range as a predictive tool (R2 = 0.69). Twelve devices, spanning a range of coil and wick styles, were analyzed. Model 1 was evaluated against twelve alternative models and displayed the best predictability. Relationships that included power settings displayed weak predictability, validating that power levels cannot be reliably compared between devices due to differing wicking and coil components and heat transfer efficiencies.

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References

Vreeke S, Korzun T, Luo W, Jensen R, Peyton D, Strongin R . Dihydroxyacetone levels in electronic cigarettes: Wick temperature and toxin formation. Aerosol Sci Technol. 2019; 52(4):370-376. PMC: 6343856. DOI: 10.1080/02786826.2018.1424316. View

Sleiman M, Logue J, Montesinos V, Russell M, Litter M, Gundel L . Emissions from Electronic Cigarettes: Key Parameters Affecting the Release of Harmful Chemicals. Environ Sci Technol. 2016; 50(17):9644-51. DOI: 10.1021/acs.est.6b01741. View

Hess C, Olmedo P, Navas-Acien A, Goessler W, Cohen J, Rule A . E-cigarettes as a source of toxic and potentially carcinogenic metals. Environ Res. 2016; 152:221-225. PMC: 5135636. DOI: 10.1016/j.envres.2016.09.026. View

Geiss O, Bianchi I, Barrero-Moreno J . Correlation of volatile carbonyl yields emitted by e-cigarettes with the temperature of the heating coil and the perceived sensorial quality of the generated vapours. Int J Hyg Environ Health. 2016; 219(3):268-77. DOI: 10.1016/j.ijheh.2016.01.004. View

Korzun T, Lazurko M, Munhenzva I, Barsanti K, Huang Y, Jensen R . E-Cigarette Airflow Rate Modulates Toxicant Profiles and Can Lead to Concerning Levels of Solvent Consumption. ACS Omega. 2018; 3(1):30-36. PMC: 5793035. DOI: 10.1021/acsomega.7b01521. View

Beauval N, Verriele M, Garat A, Fronval I, Dusautoir R, Antherieu S . Influence of puffing conditions on the carbonyl composition of e-cigarette aerosols. Int J Hyg Environ Health. 2018; 222(1):136-146. DOI: 10.1016/j.ijheh.2018.08.015. View

Soulet S, Duquesne M, Toutain J, Pairaud C, Lalo H . Influence of Coil Power Ranges on the E-Liquid Consumption in Vaping Devices. Int J Environ Res Public Health. 2018; 15(9). PMC: 6164332. DOI: 10.3390/ijerph15091853. View

Gillman I, Kistler K, Stewart E, Paolantonio A . Effect of variable power levels on the yield of total aerosol mass and formation of aldehydes in e-cigarette aerosols. Regul Toxicol Pharmacol. 2016; 75:58-65. DOI: 10.1016/j.yrtph.2015.12.019. View

Reilly S, Bitzer Z, Goel R, Trushin N, Richie J . Free Radical, Carbonyl, and Nicotine Levels Produced by Juul Electronic Cigarettes. Nicotine Tob Res. 2018; 21(9):1274-1278. PMC: 7182768. DOI: 10.1093/ntr/nty221. View

10.

Martinez-Sanchez J, Ballbe M, Perez-Ortuno R, Fu M, Sureda X, Pascual J . Secondhand exposure to aerosol from electronic cigarettes: pilot study of assessment of tobacco-specific nitrosamine (NNAL) in urine. Gac Sanit. 2018; 33(6):575-578. DOI: 10.1016/j.gaceta.2018.07.016. View

11.

Zhao J, Nelson J, Dada O, Pyrgiotakis G, Kavouras I, Demokritou P . Assessing electronic cigarette emissions: linking physico-chemical properties to product brand, e-liquid flavoring additives, operational voltage and user puffing patterns. Inhal Toxicol. 2018; 30(2):78-88. PMC: 6459014. DOI: 10.1080/08958378.2018.1450462. View

12.

Wang P, Chen W, Liao J, Matsuo T, Ito K, Fowles J . A Device-Independent Evaluation of Carbonyl Emissions from Heated Electronic Cigarette Solvents. PLoS One. 2017; 12(1):e0169811. PMC: 5226727. DOI: 10.1371/journal.pone.0169811. View

13.

Uchiyama S, Senoo Y, Hayashida H, Inaba Y, Nakagome H, Kunugita N . Determination of Chemical Compounds Generated from Second-generation E-cigarettes Using a Sorbent Cartridge Followed by a Two-step Elution Method. Anal Sci. 2016; 32(5):549-55. DOI: 10.2116/analsci.32.549. View

14.

Breland A, Soule E, Lopez A, Ramoa C, El-Hellani A, Eissenberg T . Electronic cigarettes: what are they and what do they do?. Ann N Y Acad Sci. 2016; 1394(1):5-30. PMC: 4947026. DOI: 10.1111/nyas.12977. View

15.

Jensen R, Strongin R, Peyton D . Solvent Chemistry in the Electronic Cigarette Reaction Vessel. Sci Rep. 2017; 7:42549. PMC: 5307352. DOI: 10.1038/srep42549. View

16.

Vreeke S, Peyton D, Strongin R . Triacetin Enhances Levels of Acrolein, Formaldehyde Hemiacetals, and Acetaldehyde in Electronic Cigarette Aerosols. ACS Omega. 2018; 3(7):7165-7170. PMC: 6068691. DOI: 10.1021/acsomega.8b00842. View

17.

Saliba N, El Hellani A, Honein E, Salman R, Talih S, Zeaiter J . Surface Chemistry of Electronic Cigarette Electrical Heating Coils: Effects of Metal Type on Propylene Glycol Thermal Decomposition. J Anal Appl Pyrolysis. 2019; 134:520-525. PMC: 6428435. DOI: 10.1016/j.jaap.2018.07.019. View

18.

Robinson R, Eddingsaas N, DiFrancesco A, Jayasekera S, Hensel Jr E . A framework to investigate the impact of topography and product characteristics on electronic cigarette emissions. PLoS One. 2018; 13(11):e0206341. PMC: 6218035. DOI: 10.1371/journal.pone.0206341. View

19.

Talih S, Salman R, Karaoghlanian N, El-Hellani A, Saliba N, Eissenberg T . "Juice Monsters": Sub-Ohm Vaping and Toxic Volatile Aldehyde Emissions. Chem Res Toxicol. 2017; 30(10):1791-1793. DOI: 10.1021/acs.chemrestox.7b00212. View

20.

El-Hellani A, Salman R, El-Hage R, Talih S, Malek N, Baalbaki R . Nicotine and Carbonyl Emissions From Popular Electronic Cigarette Products: Correlation to Liquid Composition and Design Characteristics. Nicotine Tob Res. 2016; 20(2):215-223. PMC: 5896517. DOI: 10.1093/ntr/ntw280. View