Efflux Pump Antibiotic Binding Site Mutations Are Associated with Azithromycin Nonsusceptibility in Clinical Neisseria Gonorrhoeae Isolates

Overview

Journal mBio

Publisher American Society for Microbiology

Specialty Microbiology

Date 2020 Aug 27

PMID 32843551

Citations 14

Authors

Kevin C Ma

Tatum D Mortimer

Yonatan H Grad

Affiliations

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Citing Articles

Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistance.

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Impact of mutations in the mtrR, rpdlVD and rrl genes on azithromycin resistance in Neisseria gonorrhoeae.

Mauffrey F, Poncet F, Jacot D, Greub G, Nordmann P, Blanc D PLoS One. 2024; 19(7):e0306695.

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The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.

Unemo M, Sanchez-Buso L, Golparian D, Jacobsson S, Shimuta K, Lan P J Antimicrob Chemother. 2024; 79(8):1885-1899.

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Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles.

Trampari E, Prischi F, Vargiu A, Abi-Assaf J, Bavro V, Webber M NPJ Antimicrob Resist. 2024; 1(1):2.

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References

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Ma K, Mortimer T, Duckett M, Hicks A, Wheeler N, Sanchez-Buso L . Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae. Nat Commun. 2020; 11(1):5374. PMC: 7584619. DOI: 10.1038/s41467-020-19250-6. View

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