Molecular Docking Analysis of Piperine with CDK2,CDK4,Cyclin D and Cyclin T Proteins

Overview

Journal Bioinformation

Specialty Biology

Date 2020 Aug 25

PMID 32831516

Citations 4

Authors

Umapathy Vidhya Rekha

M Anita

Govindaraj Jayamathi

K Sadhana

Subramanian Deepa

Sajid Hussain

J Bhuvaneswari

V Ramya

Jayaraman Selvaraj

N S Naveenraj

Affiliations

Soon will be listed here.

Abstract

Piperine is a component of Piper nigrum (Black pepper). It is well known in ayurvedic formulations. Piperine is a bioenhancer as it reduces the activity of drug-metabolizing enzymes in rodents and thereby enhancing the plasma concentrations of several drugs, including the Pglycoprotein substrates. Therefore, it is of interest to understand the molecular docking interactions of piperine with several cell cycle proteins such as Cyclin dependent kinase 2 (CDK2), Cyclin-dependent kinase 4 (CDK4), Cyclin D and Cyclin T for further consideration in drug discovery related to oral cancer.

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