Thromboembolic Complications of COVID-19: the Combined Effect of a Pro-coagulant Pattern and an Endothelial Thrombo-inflammatory Syndrome

Overview

Journal Clin Radiol

Specialty Radiology

Date 2020 Aug 25

PMID 32829885

Citations 13

Authors

F Vernuccio

F P Lombardo

R Cannella

F Panzuto

D Giambelluca

M Arzanauskaite

M Midiri

P Cabassa

Affiliations

Soon will be listed here.

Abstract

Coronavirus disease 2019 (COVID-19) is a newly emerging human infectious disease that has quickly become a worldwide threat to health, mainly causing severe acute respiratory syndrome. In addition to the widely described respiratory syndrome, COVID-19 may cause life-treating complications directly or indirectly related to this infection. Among these, thrombotic complications have emerged as an important issue in patients with COVID-19 infection, particularly in patients in intensive care units. Thrombotic complications due to COVID-19 are likely to occur due to a pro-coagulant pattern encountered in some of these patients or to a progressive endothelial thrombo-inflammatory syndrome causing microvascular disease. In the present authors' experience, from five different hospitals in Italy and the UK, imaging has proved its utility in identifying these COVID-19-related thrombotic complications, with translational clinical relevance. The aim of this review is to illustrate thromboembolic complications directly or indirectly related to COVID-19 disease. Specifically, this review will show complications related to thromboembolism due to a pro-coagulant pattern from those likely related to an endothelial thrombo-inflammatory syndrome.

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