Potential Role of Extracellular CIRP in Alcohol-Induced Alzheimer's Disease

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2020 Aug 23

PMID 32827106

Citations 8

Authors

Archna Sharma

Max Brenner

Ping Wang

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is the sixth leading cause of death in the USA and the most common form of neurodegenerative dementia. In AD, microtubule-associated protein tau becomes pathologically phosphorylated and aggregated, leading to neurodegeneration and the cognitive deficits that characterize the disease. Prospective studies have shown that frequent and heavy alcohol drinking is linked to early onset and increased severity of AD. The precise mechanisms of how alcohol leads to AD, however, remain poorly understood. We have shown that extracellular cold-inducible RNA-binding protein (eCIRP) is a critical mediator of memory impairment induced by exposure to binge-drinking levels of alcohol, leading us to reason that eCIRP may be a key player in the relationship between alcohol and AD. In this review, we first discuss the mechanisms by which alcohol promotes AD. We then review eCIRP's role as a critical mediator of acute alcohol intoxication-induced neuroinflammation and cognitive impairment. Next, we explore the potential contribution of eCIRP to the development of alcohol-induced AD by targeting tau phosphorylation. We also consider the effects of eCIRP on neuronal death and neurogenesis linking alcohol with AD. Finally, we highlight the importance of further studying eCIRP as a critical molecular mechanism connecting acute alcohol intoxication, neuroinflammation, and tau phosphorylation in AD along with the potential of therapeutically targeting eCIRP as a new strategy to attenuate alcohol-induced AD.

Citing Articles

Cold Inducible RNA-Binding Protein Promotes the Development of Alzheimer's Disease Partly by Inhibition of uPA in Astrocytes.

Li Z, Liu J, Yao F, Cao Y, Li S, Liu Y Degener Neurol Neuromuscul Dis. 2025; 14:143-155.

PMID: 39741909 PMC: 11687300. DOI: 10.2147/DNND.S490526.

The Effect of Alcohol Consumption on Progressive Supranuclear Palsy: A Cross-Sectional Study.

Tian M, Zhang B, Liu H, Han Y, Yang M, Duan R CNS Neurosci Ther. 2024; 30(12):e70146.

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Extracellular cold-inducible RNA-binding protein mediated neuroinflammation and neuronal apoptosis after traumatic brain injury.

Liu Y, Zhao M, Yu Y, Liu J, Liu W, Yao R Burns Trauma. 2024; 12:tkae004.

PMID: 38817684 PMC: 11136617. DOI: 10.1093/burnst/tkae004.

Serum cold-inducible RNA-binding protein (CIRP) levels as a prognostic indicator in patients with acute ischemic stroke.

Li M, Yao M, Shao K, Shen X, Ge Z, Li Y Front Neurol. 2023; 14:1211108.

PMID: 37521290 PMC: 10381024. DOI: 10.3389/fneur.2023.1211108.

Exosome-derived CIRP: An amplifier of inflammatory diseases.

Han J, Zhang Y, Ge P, Dakal T, Wen H, Tang S Front Immunol. 2023; 14:1066721.

PMID: 36865547 PMC: 9971932. DOI: 10.3389/fimmu.2023.1066721.

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