The Genetic Effect on Muscular Changes in an Older Population: A Follow-Up Study After One-Year Cessation of Structured Training

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2020 Aug 23

PMID 32825595

Citations 1

Authors

Lingxiao He

Evelien Van Roie

An Bogaerts

Sabine Verschueren

Christophe Delecluse

Christopher I Morse

Martine Thomis

Affiliations

Soon will be listed here.

Abstract

Older adults lose muscle mass and strength at different speeds after the cessation of physical exercise, which might be genotype related. This study aimed to explore the genetic association with changes in muscle mass and strength one year after the cessation of structured training in an older population. Participants ( = 113, aged between 61 and 81 years) who performed one-year of combined fitness ( = 44) or whole-body vibration ( = 69) training were assessed one year after the cessation of the training. Whole-body skeletal muscle mass and knee strength were measured. Data-driven genetic predisposition scores (GPSs) were calculated and analysed in a general linear model with sex, age, body mass index and post-training values of skeletal muscle mass or muscle strength as covariates. Forty-six single nucleotide polymorphisms (SNPs) from an initial 170 muscle-related SNPs were identified as being significantly linked to muscular changes after cessation. Data-driven GPSs and over time muscular changes were significantly related ( < 0.01). Participants with higher GPSs had less muscular declines during the cessation period while data-driven GPSs accounted for 26-37% of the phenotypic variances. Our findings indicate that the loss of training benefits in older adults is partially genotype related.

Citing Articles

Three-Month vs. One-Year Detraining Effects after Multicomponent Exercise Program in Hypertensive Older Women.

Leitao L, Marocolo M, DE Souza H, Arriel R, Campos Y, Mazini M Int J Environ Res Public Health. 2022; 19(5).

PMID: 35270564 PMC: 8910620. DOI: 10.3390/ijerph19052871.

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