Antifungal Activity of Phenolic and Polyphenolic Compounds from Different Matrices of L. Against Human Pathogens

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Aug 23

PMID 32824589

Citations 33

Authors

Giovanna Simonetti

Elisa Brasili

Gabriella Pasqua

Affiliations

Soon will be listed here.

Abstract

Phenolic compounds, the most widely distributed class of natural products in the plants, show several biological properties including antifungal activity. Phenolics contained in grapes can be classified in two main groups, flavonoids and non-flavonoids compounds. Variability and yield extraction of phenolic and polyphenolic compounds from different matrices of depends of cultivar, climate, soil condition and process technology. Unripe grapes, berry skins and seeds, leaves, canes and stems and not-fermented and fermented pomaces represent large reusable and valuable wastes from agricultural and agro-industrial processes. This review summarizes studies that examine the extraction method, chemical characterization, and antifungal activity of phenolic and polyphenolic compounds from edible and non-edible matrices against human fungal pathogens. In the world, around one billion people have fungal diseases related to skin, nail or hair and around 150 million have systemic diseases caused by fungi. Few studies on antifungal activity of plant extracts have been performed. This review provides useful information for the application of phenolics in the field of antifungals for human use.

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