Involvement of JNK1 in Neuronal Polarization During Brain Development

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2020 Aug 23

PMID 32823764

Citations 7

Authors

Ruben Dario Castro-Torres

Oriol Busquets

Antoni Parcerisas

Ester Verdaguer

Jordi Olloquequi

Miren Ettcheto

Carlos Beas-Zarate

Jaume Folch

Antoni Camins

Carme Auladell

Affiliations

Soon will be listed here.

Abstract

The c-Jun N-terminal Kinases (JNKs) are a group of regulatory elements responsible for the control of a wide array of functions within the cell. In the central nervous system (CNS), JNKs are involved in neuronal polarization, starting from the cell division of neural stem cells and ending with their final positioning when migrating and maturing. This review will focus mostly on isoform JNK1, the foremost contributor of total JNK activity in the CNS. Throughout the text, research from multiple groups will be summarized and discussed in order to describe the involvement of the JNKs in the different steps of neuronal polarization. The data presented support the idea that isoform JNK1 is highly relevant to the regulation of many of the processes that occur in neuronal development in the CNS.

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