Current Insights in Genetics of Sarcoidosis: Functional and Clinical Impacts

Overview

Journal J Clin Med

Specialty General Medicine

Date 2020 Aug 23

PMID 32823753

Citations 32

Authors

Alain Calender

Thomas Weichhart

Dominique Valeyre

Yves Pacheco

Affiliations

Soon will be listed here.

Abstract

Sarcoidosis is a complex disease that belongs to the vast group of autoinflammatory disorders, but the etiological mechanisms of which are not known. At the crosstalk of environmental, infectious, and genetic factors, sarcoidosis is a multifactorial disease that requires a multidisciplinary approach for which genetic research, in particular, next generation sequencing (NGS) tools, has made it possible to identify new pathways and propose mechanistic hypotheses. Codified treatments for the disease cannot always respond to the most progressive forms and the identification of new genetic and metabolic tracks is a challenge for the future management of the most severe patients. Here, we review the current knowledge regarding the genes identified by both genome wide association studies (GWAS) and whole exome sequencing (WES), as well the connection of these pathways with the current research on sarcoidosis immune-related disorders.

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