Development of a Facile Fluorophosphonate-functionalised Titanium Surface for Potential Orthopaedic Applications

Overview

Journal J Orthop Translat

Publisher Elsevier

Specialty Orthopedics

Date 2020 Aug 21

PMID 32818135

Citations 3

Authors

Anna I Shiel

Wayne N Ayre

Ashley W Blom

Keith R Hallam

Peter J Heard

Oliver Payton

Loren Picco

Jason P Mansell

Affiliations

Soon will be listed here.

Abstract

Background: Aseptic loosening of total joint replacements (TJRs) continues to be the main cause of implant failures. The socioeconomic impact of surgical revisions is hugely significant; in the United Kingdom alone, it is estimated that £137 m is spent annually on revision arthroplasties. Enhancing the longevity of titanium implants will help reduce the incidence and overall cost of failed devices.

Methods: In realising the development of a superior titanium technology, we exploited the natural affinity of titanium for phosphonic acids and developed a facile means of coating the metal with (3S)1-fluoro-3-hydroxy-4-(oleoyloxy)butyl-1-phosphonate (FHBP), a phosphatase-resistant analogue of lysophosphatidic acid (LPA). Importantly LPA and selected LPA analogues like FHBP synergistically cooperate with calcitriol to promote human osteoblast formation and maturation.

Results: Herein, we provide evidence that simply immersing titanium in aqueous solutions of FHBP afforded a surface that was superior to unmodified metal at enhancing osteoblast maturation. Importantly, FHBP-functionalised titanium remained stable to 2 years of ambient storage, resisted ∼35 kGy of gamma irradiation and survived implantation into a bone substitute (Sawbone™) and irrigation.

Conclusion: The facile step we have taken to modify titanium and the robustness of the final surface finish are appealing properties that are likely to attract the attention of implant manufacturers in the future.

The Translational Potential Of This Article: We have generated a functionalised titanium (Ti) surface by simply immersing Ti in aqueous solutions of a bioactive lipid. As a facile procedure it will have greater appeal to implant manufacturers compared to onerous and costly developmental processes.

Citing Articles

An N-Cyanoamide Derivative of Lithocholic Acid Co-Operates with Lysophosphatidic Acid to Promote Human Osteoblast (MG63) Differentiation.

Mansell J, Tanatani A, Kagechika H Biomolecules. 2023; 13(7).

PMID: 37509149 PMC: 10377543. DOI: 10.3390/biom13071113.

ZnO nanoparticles attenuate polymer-wear-particle induced inflammatory osteolysis by regulating the MEK-ERK-COX-2 axis.

Meng X, Zhang W, Lyu Z, Long T, Wang Y J Orthop Translat. 2022; 34:1-10.

PMID: 35531425 PMC: 9046564. DOI: 10.1016/j.jot.2022.04.001.

Polydopamine-Lysophosphatidate-Functionalised Titanium: A Novel Hybrid Surface Finish for Bone Regenerative Applications.

Baldwin F, Craig T, Shiel A, Cox T, Lee K, Mansell J Molecules. 2020; 25(7).

PMID: 32235562 PMC: 7180599. DOI: 10.3390/molecules25071583.

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