COVID-19: Fighting the Invisible Enemy with MicroRNAs

Overview

Journal Expert Rev Anti Infect Ther

Specialty Infectious Diseases

Date 2020 Aug 21

PMID 32814446

Citations 50

Authors

Neeraj Chauhan

Meena Jaggi

Subhash C Chauhan

Murali M Yallapu

Affiliations

Soon will be listed here.

Abstract

Introduction: The novel coronavirus (CoV) disease 2019 (COVID-19) is a viral infection that causes severe acute respiratory syndrome (SARS). It is believed that early reports of COVID-19 cases were noticed in December 2019 and soon after it became a global public health emergency. It is advised that COVID-19 transmits through human to human contact and in most cases, it remains asymptomatic. Several approaches are being utilized to control the outbreak of this fatal viral disease. microRNAs (miRNAs) are known signature therapeutic tool for the viral diseases; they are small non-coding RNAs that target the mRNAs to inhibit their post-transcriptional expression, therefore, impeding their functions, can serve as watchdogs or micromanagers in the cells.

Areas Covered: This review work delineated COVID-19 and its association with SARS and Middle East respiratory syndrome (MERS), the possible role of miRNAs in the pathogenesis of COVID-19, and therapeutic potential of miRNAs and their effective delivery to treat COVID-19.

Expert Opinion: This review highlighted the importance of various miRNAs and their potential role in fighting with this pandemic as therapeutic molecules utilizing nanotechnology.

Citing Articles

Changes in miRNA Pattern Expression Associated With COVID-19 Severity.

Zarate-Segura P, Martinez-Castillo M, Garduno-Gutierrez A, Hernandez-Hernandez J, Cano-Martinez L, Garcia-Mena J In Vivo. 2024; 39(1):482-490.

PMID: 39740904 PMC: 11705121. DOI: 10.21873/invivo.13852.

Decoding the intricacies: a comprehensive analysis of microRNAs in the pathogenesis, diagnosis, prognosis and therapeutic strategies for COVID-19.

Smail S, Hirmiz S, Ahmed A, Albarzinji N, Awla H, Amin K Front Med (Lausanne). 2024; 11:1430974.

PMID: 39434774 PMC: 11492531. DOI: 10.3389/fmed.2024.1430974.

Correlation of miR-150, hsa-let-7e, and miR- 146a and gene expression of , and during dengue virus infection.

Masyeni S, Kuntaman K, Aryati A, Sofro M, Hadi U, Mastutik G Narra J. 2024; 1(1):e31.

PMID: 38449776 PMC: 10914058. DOI: 10.52225/narraj.v1i1.31.

Evaluation of the Relationship Between Serum miR-200b-3p and miR-214-3p Expression Levels with Soluble ACE2 and TMPRSS2 in COVID-19 Patients.

Mortazavi F, Soltanshahi M, Tamaddon G Iran J Pharm Res. 2024; 22(1):e137832.

PMID: 38444707 PMC: 10912867. DOI: 10.5812/ijpr-137832.

Expression patterns of lncRNA MALAT-1 in SARS-COV-2 infection and its potential effect on disease severity via miR-200c-3p and SIRT1.

Shaker O, El Amir M, Elfatah Y, Elwi H Biochem Biophys Rep. 2023; 36:101562.

PMID: 37965063 PMC: 10641570. DOI: 10.1016/j.bbrep.2023.101562.

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