Combined Dimercaptosuccinic Acid and Zinc Treatment in Neurological Wilson's Disease Patients with Penicillamine-induced Allergy or Early Neurological Deterioration

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2020 Aug 19

PMID 32809015

Citations 4

Authors

Xiao-Qun Zhu

Liang-Yong Li

Wen-Ming Yang

Yu Wang

Affiliations

Soon will be listed here.

Abstract

The clinical data of safety and efficacy of a combined treatment with dimercaptosuccinic acid (DMSA) and Zinc with 2 years' follow-up in 60 neurological Wilson's disease (WD) patients was retrospectively analyzed. All the patients included in the present study were newly diagnosed and initialized with D-penicillamine (DPA) treatment but were found to have either neurological deterioration or allergy, and their treatment was switched to a combined treatment of DMSA and Zinc. Fifty-one patients (85%) had the neurological symptoms improved 1 and 2 years after treatment, 7 (11.67%) experienced a stable neurological condition, and 2 (3.33%) suffered deterioration of neurological symptoms. No early neurological deterioration was observed in all patients. Twenty-five percent patients experienced mild adverse reactions which did not require a discontinuation of the DMSA and Zinc treatment. Our study confirmed the safety and efficacy of the combined DMSA and Zinc therapy as an initial and probably long-term treatment in neurological WD patients.

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