Stereotactic Radiotherapy for Large Vestibular Schwannomas: Volume Change Following Single Fraction Versus Hypofractionated Approaches

Overview

Journal J Radiosurg SBRT

Date 2020 Aug 18

PMID 32802574

Citations 4

Authors

Michael Huo

Heath Foley

Mark Pinkham

Mihir Shanker

Anne Bernard

Michael Jenkins

Sarah Olson

Bruce Hall

Trevor Watkins

Catherine Jones

Matthew Foote

Affiliations

Soon will be listed here.

Abstract

Hypofractionated stereotactic radiotherapy is a treatment option for large vestibular schwannomas supported by an increasing evidence. A single institution retrospective review of large (>3.5cc) vestibular schwannomas treated with hypofractionated stereotactic radiotherapy and single-session radiosurgery was conducted. Using serial follow up scans, a volumetric analysis of tumor volume change over time was performed. Vestibular schwannomas treated with hypofractionated stereotactic radiotherapy appeared to reduce in volume significantly faster than those treated with single-session radiosurgery. Cystic lesions reduced in volume faster than solid lesions. There was no significant difference in the rates of radiological and symptomatic oedema, nor subsequent dexamethasone requirement between the two treatment modalities.

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