Amniotic Membrane Transplantation in Ophthalmology: An Updated Perspective

Overview

Journal Clin Ophthalmol

Publisher Dove Medical Press

Specialty Ophthalmology

Date 2020 Aug 18

PMID 32801614

Citations 46

Authors

Andrew Walkden

Affiliations

Soon will be listed here.

Abstract

Aim: The aim of this paper is to provide a succinct literature review of the different clinical applications for AMT usage in an ophthalmic setting, ranging from commonly used applications to less mainstream approaches. The hope is that this review enables the reader to have a better understanding of the biological properties of amnion as well as the indications and scenarios in which AMT can be used, whilst presenting relevant evidence from within the literature which may be of interest. We also provide an update on the methods of preservation of amniotic membrane and the application methodologies.

Methods: Literature search. A PubMed search was performed using the search terms "amniotic membrane transplant", "amnion AND cornea", amnion AND ophthalmology", "amnion AND ocular surface" and "Amnion AND eye". A full review of the literature using the PubMed database was conducted up until 01/05/20. The articles used were written in English, with all articles accessed in full. Both review articles and original articles were used for this review. All full publications related to ophthalmology were considered.

Citing Articles

Use of an Eyelid Pressure Patch Concomitantly with a Decellularized Dehydrated Amniotic Membrane for Ocular Surface Disease Management.

Linsey K Ophthalmol Ther. 2025; 14(3):573-584.

PMID: 39899264 PMC: 11825428. DOI: 10.1007/s40123-025-01094-2.

Dehydrated amniotic membrane patch for the treatment of an ocular event secondary to mirvetuximab soravtansine-gynx (MIRV) therapy.

File B, Hari A, Bei L Gynecol Oncol Rep. 2024; 56:101547.

PMID: 39640287 PMC: 11617700. DOI: 10.1016/j.gore.2024.101547.

Clinically correlated dose of the amniotic membrane extract is superior to its transplantation in corneal wound healing.

Korkmaz I, Kocamanoglu M, Gurdal M, Arici M, Yaman B, Palamar M Mol Vis. 2024; 30:188-199.

PMID: 39563677 PMC: 11575842.

The use of amniotic membrane injection as an adjunct in endoscopic urethral stricture management.

Pryde N, Vercnocke J, Lutchka J, Liaw A, Sessine M, Dhar N Indian J Urol. 2024; 40(4):256-258.

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3D morphometry of endothelial cells angiogenesis in an extracellular matrix composite hydrogel.

Heidari F, Shamshiripour P, Rahnama M, Saadatmand M, Ahmadvand D, Simorgh S Heliyon. 2024; 10(21):e39616.

PMID: 39524796 PMC: 11546153. DOI: 10.1016/j.heliyon.2024.e39616.

References

Eliezer R, Kasahara N, Caixeta-Umbelino C, Pinheiro R, Mandia Jr C, Malta R . Use of amniotic membrane in trabeculectomy for the treatment of glaucoma: a pilot study. Arq Bras Oftalmol. 2006; 69(3):309-12. DOI: 10.1590/s0004-27492006000300005. View

Wu Z, Hui G . Materials for neuro-transplantation and the amnion. Chin Med J (Engl). 2006; 119(16):1323-6. View

Li W, Hayashida Y, He H, Kuo C, Tseng S . The fate of limbal epithelial progenitor cells during explant culture on intact amniotic membrane. Invest Ophthalmol Vis Sci. 2007; 48(2):605-13. PMC: 3197022. DOI: 10.1167/iovs.06-0514. View

Sun C, Pang J, Cheng C, Cheng H, Lee Y, Ku W . Interleukin-1 receptor antagonist (IL-1RA) prevents apoptosis in ex vivo expansion of human limbal epithelial cells cultivated on human amniotic membrane. Stem Cells. 2006; 24(9):2130-9. DOI: 10.1634/stemcells.2005-0590. View

Grueterich M, Tseng S . Human limbal progenitor cells expanded on intact amniotic membrane ex vivo. Arch Ophthalmol. 2002; 120(6):783-90. DOI: 10.1001/archopht.120.6.783. View

Ti S, Tow S, Chee S . Amniotic membrane transplantation in entropion surgery. Ophthalmology. 2001; 108(7):1209-17. DOI: 10.1016/s0161-6420(01)00599-1. View

Boudreau N, Sympson C, Werb Z, Bissell M . Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science. 1995; 267(5199):891-3. PMC: 3004777. DOI: 10.1126/science.7531366. View

Sangwan V, Basu S, Vemuganti G, Sejpal K, Subramaniam S, Bandyopadhyay S . Clinical outcomes of xeno-free autologous cultivated limbal epithelial transplantation: a 10-year study. Br J Ophthalmol. 2011; 95(11):1525-9. DOI: 10.1136/bjophthalmol-2011-300352. View

Fukuda K, Chikama T, Nakamura M, Nishida T . Differential distribution of subchains of the basement membrane components type IV collagen and laminin among the amniotic membrane, cornea, and conjunctiva. Cornea. 1999; 18(1):73-9. View

10.

Rock T, Bartz-Schmidt K, Landenberger J, Bramkamp M, Rock D . Amniotic Membrane Transplantation in Reconstructive and Regenerative Ophthalmology. Ann Transplant. 2018; 23:160-165. PMC: 6248296. View

11.

Kitagawa K, Yanagisawa S, Watanabe K, Yunoki T, Hayashi A, Okabe M . A hyperdry amniotic membrane patch using a tissue adhesive for corneal perforations and bleb leaks. Am J Ophthalmol. 2009; 148(3):383-9. DOI: 10.1016/j.ajo.2009.03.030. View

12.

Khokhar S, Natung T, Sony P, Sharma N, Agarwal N, Vajpayee R . Amniotic membrane transplantation in refractory neurotrophic corneal ulcers: a randomized, controlled clinical trial. Cornea. 2005; 24(6):654-60. DOI: 10.1097/01.ico.0000153102.19776.80. View

13.

Kassem R, El-Mofty R . Amniotic Membrane Transplantation in Strabismus Surgery. Curr Eye Res. 2018; 44(5):451-464. DOI: 10.1080/02713683.2018.1562555. View

14.

Karteris E, Grammatopoulos D, Dai Y, Olah K, Ghobara T, Easton A . The human placenta and fetal membranes express the corticotropin-releasing hormone receptor 1alpha (CRH-1alpha) and the CRH-C variant receptor. J Clin Endocrinol Metab. 1998; 83(4):1376-9. DOI: 10.1210/jcem.83.4.4705. View

15.

Rinastiti M, Harijadi , Santoso A, Sosroseno W . Histological evaluation of rabbit gingival wound healing transplanted with human amniotic membrane. Int J Oral Maxillofac Surg. 2006; 35(3):247-51. DOI: 10.1016/j.ijom.2005.09.012. View

16.

Caporossi T, Pacini B, De Angelis L, Barca F, Peiretti E, Rizzo S . HUMAN AMNIOTIC MEMBRANE TO CLOSE RECURRENT, HIGH MYOPIC MACULAR HOLES IN PATHOLOGIC MYOPIA WITH AXIAL LENGTH OF ≥30 mm. Retina. 2019; 40(10):1946-1954. DOI: 10.1097/IAE.0000000000002699. View

17.

Niknejad H, Yazdanpanah G, Mirmasoumi M, Abolghasemi H, Peirovi H, Ahmadiani A . Inhibition of HSP90 could be possible mechanism for anti-cancer property of amniotic membrane. Med Hypotheses. 2013; 81(5):862-5. DOI: 10.1016/j.mehy.2013.08.018. View

18.

Tsai , Li , Chen . Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells(1). Am J Ophthalmol. 2000; 130(4):543. DOI: 10.1016/s0002-9394(00)00746-7. View

19.

Kolomeyer A, Do B, Tu Y, Chu D . Placement of ProKera in the management of ocular manifestations of acute Stevens-Johnson syndrome in an outpatient. Eye Contact Lens. 2012; 39(3):e7-11. DOI: 10.1097/ICL.0b013e318255124f. View

20.

Liu J, Li L, Li X . Effectiveness of Cryopreserved Amniotic Membrane Transplantation in Corneal Ulceration: A Meta-Analysis. Cornea. 2019; 38(4):454-462. DOI: 10.1097/ICO.0000000000001866. View