Aminoglycosides: From Antibiotics to Building Blocks for the Synthesis and Development of Gene Delivery Vehicles

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2020 Aug 16

PMID 32796727

Citations 9

Authors

Maria Cristina Bellucci

Alessandro Volonterio

Affiliations

Soon will be listed here.

Abstract

Aminoglycosides are a class of naturally occurring and semi synthetic antibiotics that have been used for a long time in fighting bacterial infections. Due to acquired antibiotic resistance and inherent toxicity, aminoglycosides have experienced a decrease in interest over time. However, in the last decade, we are seeing a renaissance of aminoglycosides thanks to a better understanding of their chemistry and mode of action, which had led to new trends of application. The purpose of this comprehensive review is to highlight one of these new fields of application: the use of aminoglycosides as building blocks for the development of liposomal and polymeric vectors for gene delivery. The design, synthetic strategies, ability to condensate the genetic material, the efficiency in transfection, and cytotoxicity as well as when available, the antibacterial activity of aminoglycoside-based cationic lipids and polymers are covered and critically analyzed.

Citing Articles

Dual Antibiotic Approach: Synthesis and Antibacterial Activity of Antibiotic-Antimicrobial Peptide Conjugates.

Bellucci M, Romani C, Sani M, Volonterio A Antibiotics (Basel). 2024; 13(8).

PMID: 39200083 PMC: 11352213. DOI: 10.3390/antibiotics13080783.

Restoring susceptibility to aminoglycosides: identifying small molecule inhibitors of enzymatic inactivation.

Magana A, Sklenicka J, Pinilla C, Giulianotti M, Chapagain P, Santos R RSC Med Chem. 2023; 14(9):1591-1602.

PMID: 37731693 PMC: 10507813. DOI: 10.1039/d3md00226h.

Antibiotic Susceptibility Testing with Raman Biosensing.

Novikov A, Sayfutdinova A, Botchkova E, Kopitsyn D, Fakhrullin R Antibiotics (Basel). 2022; 11(12).

PMID: 36551469 PMC: 9774239. DOI: 10.3390/antibiotics11121812.

KasQ an Epimerase Primes the Biosynthesis of Aminoglycoside Antibiotic Kasugamycin and KasF/H Acetyltransferases Inactivate Its Activity.

Rattinam R, Basha R, Wang Y, Wang Z, Hsu N, Lin K Biomedicines. 2022; 10(2).

PMID: 35203422 PMC: 8869731. DOI: 10.3390/biomedicines10020212.

Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes.

Le Gall T, Berchel M, Davies L, Mottais A, Ghanem R, Fautrel A Pharmaceutics. 2022; 14(1).

PMID: 35056921 PMC: 8778791. DOI: 10.3390/pharmaceutics14010025.

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