Invadopodia: Clearing the Way for Cancer Cell Invasion

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2020 Aug 15

PMID 32793746

Citations 29

Authors

Katarzyna Augoff

Anita Hryniewicz-Jankowska

Renata Tabola

Affiliations

Soon will be listed here.

Abstract

The invasive nature of many cancer cells involves the formation of F-actin-based, lipid-raft-enriched membrane protrusions known as invadopodia or, more broadly, invadosomes. Invadopodia are specialized adhesive structures arising from ventral cell surface within cell-extracellular matrix (ECM) contacts and concentrate high proteolytic activities that allow cells to overcome the dense scaffold of local microenvironment, comprising a natural barrier to cell spreading. This degradative activity distinguishes invadopodia from other adhesive structures like focal adhesions, lamellipodia or filopodia, and is believed to drive cancer progression.

Citing Articles

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