Emerging Role of FBXO22 in Carcinogenesis

Overview

Journal Cell Death Discov

Date 2020 Aug 15

PMID 32793396

Citations 22

Authors

Jiangting Cheng

Min Lin

Man Chu

Longyuan Gong

Yanli Bi

Yongchao Zhao

Affiliations

Soon will be listed here.

Abstract

The F-box protein 22 (FBXO22), one of F-box proteins, has been identified to be critically involved in carcinogenesis. FBXO22 promotes proliferation in breast cancer and lung cancer, but suppresses migration and metastasis. FBXO22 exerts oncogenetic functions via promoting the ubiquitination and degradation of its substrates, including KDM4A, KDM4B, methylated p53, p21, KLF4, LKB1, Snail, CD147, Bach1, PTEN, and HDM2. FBXO22 is also regulated by several regulatory factors such as p53, miR-155, SNHG14, and circ_0006282. In this review, we summarize the regulatory factors and downstream targets of FBXO22 in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies. Finally, we provide novel insights for future perspectives on targeting FBXO22 as a promising strategy for cancer therapy.

Citing Articles

The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications.

Wei X, He Y, Yu Y, Tang S, Liu R, Guo J Adv Sci (Weinh). 2025; 12(10):e2412850.

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FBXO22 promotes HCC angiogenesis and metastasis via RPS5/AKT/HIF-1α/VEGF-A signaling axis.

Lei Z, Luo Y, Lu J, Fu Q, Wang C, Chen Q Cancer Gene Ther. 2025; 32(2):198-213.

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Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress.

Cao S, Garcia S, Shi H, James E, Kito Y, Shi H Cell. 2024; 187(26):7568-7584.e22.

PMID: 39504958 PMC: 11682927. DOI: 10.1016/j.cell.2024.10.012.

Shenqifuzheng injection inhibits lactic acid-induced cisplatin resistance in NSCLC by affecting FBXO22/p53 axis through FOXO3.

Bo W, Wang X, Yu N, Wang C, Liu C Respir Res. 2024; 25(1):396.

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FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Li M, Chen X, Qu P, Shao Z, Shi L, Quan H Proc Natl Acad Sci U S A. 2024; 121(45):e2402035121.

PMID: 39485803 PMC: 11551398. DOI: 10.1073/pnas.2402035121.

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