Lutetium SPECT/CT: Evaluation of Collimator, Photopeak and Scatter Correction

Overview

Journal J Appl Clin Med Phys

Specialties Biophysics
General Medicine

Date 2020 Aug 14

PMID 32790140

Citations 9

Authors

Daphne M V Huizing

Michiel Sinaasappel

Marien C Dekker

Marcel P M Stokkel

Berlinda J de Wit-van der Veen

Affiliations

Soon will be listed here.

Abstract

Purpose: The goal of this study was to find the optimal combination of collimator, photopeak and scatter correction for Lutetium ( Lu) SPECT/CT imaging.

Methods: Three experiments [sphere-to-background ratios (SBR) 50:1, 10:1, and 2:1] were performed with the NEMA Image Quality phantom filled with Lu-trichloride. SPECT/CT acquisitions were performed with the medium-energy low-penetration (MELP) collimator and Tc/Krypton collimator. For each acquisition six reconstructions, all with attenuation correction (AC), were made: the 113-keV photopeak only, the 208-keV photopeak only and both photopeaks combined, each with or without scatter correction (SC). Image quality was assessed using contrast-to-noise ratios (CNR), quantification accuracy by means of recovery coefficients (RCs) and the spatial resolution using line profiles.

Results: With SBR 50:1 and 10:1, both collimators met the Rose criterion (CNR > 5), whereas the MELP collimator showed a higher CNR for the 2:1 ratio. The RC was higher with the MELP collimator, most explicit after the 208-keV AC/SC reconstruction for all acquisitions. The line profiles showed a better spatial resolution for the MELP collimator and the 208-keV AC/SC reconstructions.

Conclusion: Lu SPECT/CT image quality and quantification was most optimal when acquired with the MELP collimator and reconstructed using the 208-keV photopeak, with AC and SC.

Citing Articles

The SwiftScan step-and-shoot continuous mode improves SPECT scanning efficiency: a preliminary phantom and clinical test.

Li J, Zhang K, Pang X, Huang L, Tian X, Liu J EJNMMI Phys. 2025; 12(1):1.

PMID: 39745654 PMC: 11695528. DOI: 10.1186/s40658-024-00709-0.

Activity quantification and dosimetry in radiopharmaceutical therapy with reference to Lutetium.

Ramonaheng K, Qebetu M, Ndlovu H, Swanepoel C, Smith L, Mdanda S Front Nucl Med. 2024; 4:1355912.

PMID: 39355215 PMC: 11440950. DOI: 10.3389/fnume.2024.1355912.

The cycle effect quantified: reduced tumour uptake in subsequent cycles of [Lu]Lu-HA-DOTATATE during peptide receptor radionuclide therapy.

Siebinga H, Hendrikx J, de Vries-Huizing D, Huitema A, de Wit-van der Veen B Eur J Nucl Med Mol Imaging. 2023; 51(3):820-827.

PMID: 37843598 DOI: 10.1007/s00259-023-06463-2.

Reducing scan time in Lu planar scintigraphy using convolutional neural network: A Monte Carlo simulation study.

Yang C, Ko K, Lin P J Appl Clin Med Phys. 2023; 24(10):e14056.

PMID: 37261890 PMC: 10562044. DOI: 10.1002/acm2.14056.

Physics-Guided Deep Scatter Estimation by Weak Supervision for Quantitative SPECT.

Kim H, Li Z, Son J, Fessler J, Dewaraja Y, Chun S IEEE Trans Med Imaging. 2023; 42(10):2961-2973.

PMID: 37104110 PMC: 10593395. DOI: 10.1109/TMI.2023.3270868.

References

Beijst C, de Keizer B, Lam M, Janssens G, Tytgat G, W A M de Jong H . A phantom study: Should I-mIBG PET/CT replace I-mIBG SPECT/CT?. Med Phys. 2017; 44(5):1624-1631. DOI: 10.1002/mp.12202. View

de Nijs R, Lagerburg V, Klausen T, Holm S . Improving quantitative dosimetry in (177)Lu-DOTATATE SPECT by energy window-based scatter corrections. Nucl Med Commun. 2014; 35(5):522-33. PMC: 3969156. DOI: 10.1097/MNM.0000000000000079. View

Zeintl J, Vija A, Yahil A, Hornegger J, Kuwert T . Quantitative accuracy of clinical 99mTc SPECT/CT using ordered-subset expectation maximization with 3-dimensional resolution recovery, attenuation, and scatter correction. J Nucl Med. 2010; 51(6):921-8. DOI: 10.2967/jnumed.109.071571. View

Sjogreen Gleisner K, Brolin G, Sundlov A, Mjekiqi E, Ostlund K, Tennvall J . Long-Term Retention of 177Lu/177mLu-DOTATATE in Patients Investigated by γ-Spectrometry and γ-Camera Imaging. J Nucl Med. 2015; 56(7):976-84. DOI: 10.2967/jnumed.115.155390. View

Ljungberg M, Celler A, Konijnenberg M, Eckerman K, Dewaraja Y, Sjogreen-Gleisner K . MIRD Pamphlet No. 26: Joint EANM/MIRD Guidelines for Quantitative 177Lu SPECT Applied for Dosimetry of Radiopharmaceutical Therapy. J Nucl Med. 2015; 57(1):151-62. DOI: 10.2967/jnumed.115.159012. View

Wevrett J, Fenwick A, Scuffham J, Johansson L, Gear J, Schlogl S . Inter-comparison of quantitative imaging of lutetium-177 (Lu) in European hospitals. EJNMMI Phys. 2018; 5(1):17. PMC: 6070453. DOI: 10.1186/s40658-018-0213-z. View

Garkavij M, Nickel M, Sjogreen-Gleisner K, Ljungberg M, Ohlsson T, Wingardh K . 177Lu-[DOTA0,Tyr3] octreotate therapy in patients with disseminated neuroendocrine tumors: Analysis of dosimetry with impact on future therapeutic strategy. Cancer. 2010; 116(4 Suppl):1084-92. DOI: 10.1002/cncr.24796. View

Fendler W, Rahbar K, Herrmann K, Kratochwil C, Eiber M . Lu-PSMA Radioligand Therapy for Prostate Cancer. J Nucl Med. 2017; 58(8):1196-1200. DOI: 10.2967/jnumed.117.191023. View

Finocchiaro D, Berenato S, Grassi E, Bertolini V, Castellani G, Lanconelli N . Partial volume effect of SPECT images in PRRT with 177Lu labelled somatostatin analogues: A practical solution. Phys Med. 2019; 57:153-159. DOI: 10.1016/j.ejmp.2018.12.029. View

10.

Lassmann M, Eberlein U . The Relevance of Dosimetry in Precision Medicine. J Nucl Med. 2018; 59(10):1494-1499. DOI: 10.2967/jnumed.117.206649. View

11.

Chiesa C, Sjogreen Gleisner K, Flux G, Gear J, Walrand S, Bacher K . The conflict between treatment optimization and registration of radiopharmaceuticals with fixed activity posology in oncological nuclear medicine therapy. Eur J Nucl Med Mol Imaging. 2017; 44(11):1783-1786. DOI: 10.1007/s00259-017-3707-3. View

12.

Mezzenga E, DErrico V, DArienzo M, Strigari L, Panagiota K, Matteucci F . Quantitative accuracy of 177Lu SPECT imaging for molecular radiotherapy. PLoS One. 2017; 12(8):e0182888. PMC: 5564164. DOI: 10.1371/journal.pone.0182888. View

13.

Uribe C, Esquinas P, Tanguay J, Gonzalez M, Gaudin E, Beauregard J . Accuracy of Lu activity quantification in SPECT imaging: a phantom study. EJNMMI Phys. 2017; 4(1):2. PMC: 5218957. DOI: 10.1186/s40658-016-0170-3. View

14.

Peters S, Viol S, van der Werf N, de Jong N, van Velden F, Meeuwis A . Variability in lutetium-177 SPECT quantification between different state-of-the-art SPECT/CT systems. EJNMMI Phys. 2020; 7(1):9. PMC: 7013023. DOI: 10.1186/s40658-020-0278-3. View

15.

Dewaraja Y, Frey E, Sgouros G, Brill A, Roberson P, Zanzonico P . MIRD pamphlet No. 23: quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy. J Nucl Med. 2012; 53(8):1310-25. PMC: 3465844. DOI: 10.2967/jnumed.111.100123. View

16.

Strosberg J, El-Haddad G, Wolin E, Hendifar A, Yao J, Chasen B . Phase 3 Trial of Lu-Dotatate for Midgut Neuroendocrine Tumors. N Engl J Med. 2017; 376(2):125-135. PMC: 5895095. DOI: 10.1056/NEJMoa1607427. View