Gastrointestinally Digested Protein from the Insect Stimulates a Different Intestinal Secretome Than Beef or Almond, Producing a Differential Response in Food Intake in Rats

Overview

Journal Nutrients

Date 2020 Aug 14

PMID 32784756

Citations 6

Authors

Alba Miguens-Gomez

Carme Grau-Bove

Marta Sierra-Cruz

Rosa Jorba-Martin

Aleidis Caro

Esther Rodriguez-Gallego

Raul Beltran-Debon

M Teresa Blay

Ximena Terra

Anna Ardevol

Montserrat Pinent

Affiliations

Soon will be listed here.

Abstract

In this study we compare the interaction of three protein sources-insect, beef, and almond-with the gastrointestinal tract. We measured the enterohormone secretion ex vivo in human and pig intestine treated with in vitro digestions of these foods. Insect and beef were the most effective in inducing the secretion of CCK, while almond was the most effective in inducing PYY in pig duodenum. In the human colon, almond was also the most effective in inducing PYY, and GLP-1 levels were increased by insect and beef. The three digested proteins reduced ghrelin secretion in pig duodenum, while only insect reduced ghrelin secretion in human colon. We also found that food intake in rats increased in groups fed a raw insect pre-load and decreased when fed raw almond. In conclusion, the insect modulates duodenal and colonic enterohormone release and increases food intake in rats. These effects differ from beef and almond.

Citing Articles

Profiling bitter taste receptors (TAS2R) along the gastrointestinal tract and their influence on enterohormone secretion. Gender- and age-related effects in the colon.

Jalsevac F, Descamps-Sola M, Grau-Bove C, Segu H, Auguet T, Aviles-Jurado F Front Endocrinol (Lausanne). 2024; 15:1436580.

PMID: 39512758 PMC: 11541047. DOI: 10.3389/fendo.2024.1436580.

A review on edible insects in China: Nutritional supply, environmental benefits, and potential applications.

Lin X, Wang F, Lu Y, Wang J, Chen J, Yu Y Curr Res Food Sci. 2023; 7:100596.

PMID: 37744556 PMC: 10517268. DOI: 10.1016/j.crfs.2023.100596.

Inhibition of DPP-IV Activity and Stimulation of GLP-1 Release by Gastrointestinally Digested Black Soldier Fly Prepupae.

Luparelli A, Miguens-Gomez A, Ardevol A, Sforza S, Caligiani A, Pinent M Foods. 2023; 12(10).

PMID: 37238845 PMC: 10217252. DOI: 10.3390/foods12102027.

Administration of Alphitobius diaperinus or Tenebrio molitor before meals transiently increases food intake through enterohormone regulation in female rats.

Miguens-Gomez A, Sierra-Cruz M, Segu H, Beltran-Debon R, Rodriguez-Gallego E, Terra X J Sci Food Agric. 2022; 103(4):1660-1667.

PMID: 36324158 PMC: 10099498. DOI: 10.1002/jsfa.12305.

Effect of an Acute Insect Preload vs. an Almond Preload on Energy Intake, Subjective Food Consumption and Intestinal Health in Healthy Young Adults.

Miguens-Gomez A, Sierra-Cruz M, Rodriguez-Gallego E, Beltran-Debon R, Blay M, Terra X Nutrients. 2022; 14(7).

PMID: 35406076 PMC: 9002463. DOI: 10.3390/nu14071463.

References

Foster-Schubert K, Overduin J, Prudom C, Liu J, Callahan H, Gaylinn B . Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates. J Clin Endocrinol Metab. 2008; 93(5):1971-9. PMC: 2386677. DOI: 10.1210/jc.2007-2289. View

Christensen D, Orech F, Mungai M, Larsen T, Friis H, Aagaard-Hansen J . Entomophagy among the Luo of Kenya: a potential mineral source?. Int J Food Sci Nutr. 2006; 57(3-4):198-203. DOI: 10.1080/09637480600738252. View

Egger L, Schlegel P, Baumann C, Stoffers H, Guggisberg D, Brugger C . Physiological comparability of the harmonized INFOGEST in vitro digestion method to in vivo pig digestion. Food Res Int. 2017; 102:567-574. DOI: 10.1016/j.foodres.2017.09.047. View

Janssen R, Vincken J, Arts N, Fogliano V, Lakemond C . Effect of endogenous phenoloxidase on protein solubility and digestibility after processing of Tenebrio molitor, Alphitobius diaperinus and Hermetia illucens. Food Res Int. 2019; 121:684-690. DOI: 10.1016/j.foodres.2018.12.038. View

Kulma M, Kourimska L, Plachy V, Bozik M, Adamkova A, Vrabec V . Effect of sex on the nutritional value of house cricket, Acheta domestica L. Food Chem. 2018; 272:267-272. DOI: 10.1016/j.foodchem.2018.08.049. View

Youn K, Yun E, Lee J, Kim J, Hwang J, Jeong W . Oleic acid and linoleic acid from Tenebrio molitor larvae inhibit BACE1 activity in vitro: molecular docking studies. J Med Food. 2014; 17(2):284-9. DOI: 10.1089/jmf.2013.2968. View

Wu Q, Jia J, Yan H, Du J, Gui Z . A novel angiotensin-І converting enzyme (ACE) inhibitory peptide from gastrointestinal protease hydrolysate of silkworm pupa (Bombyx mori) protein: Biochemical characterization and molecular docking study. Peptides. 2014; 68:17-24. DOI: 10.1016/j.peptides.2014.07.026. View

Yi H, Chowdhury M, Huang Y, Yu X . Insect antimicrobial peptides and their applications. Appl Microbiol Biotechnol. 2014; 98(13):5807-22. PMC: 4083081. DOI: 10.1007/s00253-014-5792-6. View

Monteleone P, Bencivenga R, Longobardi N, Serritella C, Maj M . Differential responses of circulating ghrelin to high-fat or high-carbohydrate meal in healthy women. J Clin Endocrinol Metab. 2003; 88(11):5510-4. DOI: 10.1210/jc.2003-030797. View

10.

Gribble F . The gut endocrine system as a coordinator of postprandial nutrient homoeostasis. Proc Nutr Soc. 2012; 71(4):456-62. DOI: 10.1017/S0029665112000705. View

11.

Adriaenssens A, Reimann F, Gribble F . Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract. Compr Physiol. 2018; 8(4):1603-1638. DOI: 10.1002/cphy.c170047. View

12.

Boye J, Wijesinha-Bettoni R, Burlingame B . Protein quality evaluation twenty years after the introduction of the protein digestibility corrected amino acid score method. Br J Nutr. 2012; 108 Suppl 2:S183-211. DOI: 10.1017/S0007114512002309. View

13.

House J, Hill K, Neufeld J, Franczyk A, Nosworthy M . Determination of the protein quality of almonds ( L.) as assessed by in vitro and in vivo methodologies. Food Sci Nutr. 2019; 7(9):2932-2938. PMC: 6766546. DOI: 10.1002/fsn3.1146. View

14.

Oonincx D, Van Itterbeeck J, Heetkamp M, van den Brand H, van Loon J, van Huis A . An exploration on greenhouse gas and ammonia production by insect species suitable for animal or human consumption. PLoS One. 2011; 5(12):e14445. PMC: 3012052. DOI: 10.1371/journal.pone.0014445. View

15.

Calbet J, Holst J . Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrolysates in humans. Eur J Nutr. 2004; 43(3):127-39. DOI: 10.1007/s00394-004-0448-4. View

16.

Hollingworth S, Dalton M, Blundell J, Finlayson G . Evaluation of the Influence of Raw Almonds on Appetite Control: Satiation, Satiety, Hedonics and Consumer Perceptions. Nutrients. 2019; 11(9). PMC: 6769453. DOI: 10.3390/nu11092030. View

17.

Karhunen L, Juvonen K, Huotari A, Purhonen A, Herzig K . Effect of protein, fat, carbohydrate and fibre on gastrointestinal peptide release in humans. Regul Pept. 2008; 149(1-3):70-8. DOI: 10.1016/j.regpep.2007.10.008. View

18.

Wu G . Dietary protein intake and human health. Food Funct. 2016; 7(3):1251-65. DOI: 10.1039/c5fo01530h. View

19.

Geraedts M, Troost F, Fischer M, Edens L, Saris W . Direct induction of CCK and GLP-1 release from murine endocrine cells by intact dietary proteins. Mol Nutr Food Res. 2010; 55(3):476-84. DOI: 10.1002/mnfr.201000142. View

20.

Cheseto X, Kuate S, Tchouassi D, Ndungu M, Teal P, Torto B . Potential of the Desert Locust Schistocerca gregaria (Orthoptera: Acrididae) as an Unconventional Source of Dietary and Therapeutic Sterols. PLoS One. 2015; 10(5):e0127171. PMC: 4429980. DOI: 10.1371/journal.pone.0127171. View