Role of Low-molecular-weight Heparin in Altering Uterine Artery Blood Flow in Recurrent Spontaneous Abortion: a Prospective Study

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2020 Aug 12

PMID 32780610

Citations 3

Authors

Kemei Zhang

Ensheng Wang

Yang Li

Haiyan Xu

Jiaou Zhang

Xuhong Wang

Jing Shu

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to determine the role of uterine artery blood flow (UABF) in recurrent spontaneous abortion (RSA) and to determine a viable option to promote the outcome of pregnancy.

Methods: A total of 421 women were prospectively recruited for this research. UABF indices, including the systolic/diastolic ratio, pulsatility index and resistance index, during the midluteal phase were compared between patients with RSA and women without RSA (controls). After low-molecular-weight heparin (LMWH) was administered to patients with RSA, indices at 7, 10, and 12 weeks of gestation were compared between the two groups.

Results: UABF indices during the midluteal phase were significantly higher in the RSA group than in the control group. After LMWH was administered to the RSA group, UABF indices in the first trimester were similar to those in the control group. The rate of spontaneous miscarriage was also similar between the groups after LMWH treatment.

Conclusions: Our study shows that sufficient uterine perfusion is crucial for a successful pregnancy. LMWH reduces the rate of spontaneous miscarriage in patients with RSA to a similar rate in women without RSA. LMWH might play a role in decreasing UABF resistance and increasing uterine perfusion.

Citing Articles

Correlation Between Serum Markers and Midluteal Phase Doppler Assessment of Uterine Arterial Blood Flow in Unexplained Recurrent Pregnancy Loss.

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Analysis of blood coagulation indexes, thromboelastogram and autoantibodies in patients with recurrent pregnancy loss.

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Clinical Impact of Nurses-Physicians Collaboration Intervention on the Treatment of Immune Recurrent Spontaneous Abortion with Low-Molecular-Weight Heparin.

Chen M, Wang X, Deng P Evid Based Complement Alternat Med. 2021; 2021:9290720.

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