Efficacy of Adipose Derived Stem Cells on Functional and Neurological Improvement Following Ischemic Stroke: a Systematic Review and Meta-analysis

Overview

Journal BMC Neurol

Publisher Biomed Central

Specialty Neurology

Date 2020 Aug 12

PMID 32778066

Citations 4

Authors

Mahmoud Yousefifard

Jebreil Shamseddin

Asrin Babahajian

Arash Sarveazad

Affiliations

Soon will be listed here.

Abstract

Background: The evidence on the efficacy of adipose derived stem cells (ADSCs) in the treatment of stroke is controversial. Therefore, the aim of present systematic review and meta-analysis is to evaluate the efficacy of ADSCs administration in the treatment of animal models of ischemic stroke.

Methods: An extensive search was performed on electronic databases of Medline, Embase, Scopus, CENTRAL and Web of Science until December 31, 2018. Animal studies that used ADSCs in treatment of ischemic stroke were included. The data were recorded as mean and standard deviation and then a pooled standardized mean difference (SMD) with 95% confidence interval (95% CI) was reported.

Results: Twenty articles were included in the present meta-analysis. It was observed that administration of ADSCs improves motor function (SMD = 2.52, 95% CI: 1.67 to 3.37, p < 0.0001) and neurological status (SMD = 2.05, 95% CI: 1.33 to 2.78, p < 0.0001) in animals following an ischemic stroke. Multivariate meta-regression showed the model of stroke induction (p = 0.017) and the number of transplanted cells (p = 0.007) affect the efficacy of ADSCs administration on motor function improvement following the stroke.

Conclusion: Moderate to high levels of evidence indicate a strong efficacy of ADSCs transplantation on motor function and neurological improvement following ischemic stroke in animal models. However, no reports regarding the dose-response effect of ADSCs administration on stroke exist in the literature. As a result, further pre-clinical studies are recommended to be conducted on the matter.

Citing Articles

Adipose-Derived Stem Cell Therapy in Spinal Cord Injury.

El Masri J, Fadlallah H, Al Sabsabi R, Afyouni A, Al-Sayegh M, Abou-Kheir W Cells. 2024; 13(17.

PMID: 39273075 PMC: 11394073. DOI: 10.3390/cells13171505.

Mining human clinical waste as a rich source of stem cells for neural regeneration.

Eivazi Zadeh Z, Nour S, Kianersi S, Jonidi Shariatzadeh F, Williams R, Nisbet D iScience. 2024; 27(8):110307.

PMID: 39156636 PMC: 11326931. DOI: 10.1016/j.isci.2024.110307.

Mesenchymal Stem Cell-Conditioned Medium Promotes Functional Recovery Following Spinal Cord Injury: A Systematic Review and Meta-analysis.

Sarveazad A, Toloui A, Moarrefzadeh A, Nafchi H, Madani Neishaboori A, Yousefifard M Spine Surg Relat Res. 2022; 6(5):433-442.

PMID: 36348669 PMC: 9605759. DOI: 10.22603/ssrr.2022-0004.

Adipose tissue-derived stem cells as a potential candidate in treatment of Alzheimer's disease: A systematic review on preclinical studies.

Madani Neishaboori A, Eshraghi A, Tasouji Asl A, Shariatpanahi M, Yousefifard M, Gorji A Pharmacol Res Perspect. 2022; 10(4):e00977.

PMID: 35718918 PMC: 9207226. DOI: 10.1002/prp2.977.

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