Black Phosphorus Nanosheets and Docetaxel Micelles Co-incorporated Thermoreversible Hydrogel for Combination Chemo-photodynamic Therapy

Overview

Journal Drug Deliv Transl Res

Publisher Springer

Specialty Pharmacology

Date 2020 Aug 11

PMID 32776211

Citations 11

Authors

Ruirui Li

Linwei Shan

Yanan Yao

Feifei Peng

Shanshan Jiang

Dandan Yang

Guixia Ling

Peng Zhang

Affiliations

Soon will be listed here.

Abstract

The platform of the combination chemo-photodynamic therapy has received widespread attention for enhancing anticancer efficacy and inhibiting tumor growth, which supports thermosensitive and controlled drug release. Here, an injectable thermoreversible hydrogel (BPNSs/DTX-M-hydrogel) co-encapsulating black phosphorus nanosheets (BPNSs) and docetaxel (DTX) micelles was prepared to increase drug accumulation in tumor tissue and improve anticancer efficacy. BPNSs were prepared by liquid exfoliation method with a simple and rapid preparation, and DTX micelles were prepared by the thin film dispersion method. Hydrogel was prepared with F127 as hydrogel matrix for intratumoral injection. BPNSs, DTX micelles, and BPNSs/DTX-M-hydrogel were characterized by particle size, morphology, stability and degradation, phase transition feature, and photodynamic performance. And the in vivo anticancer efficacy was evaluated in 4T1 tumor-bearing Balb/c mice. The results showed that the particle size of DTX micelles and BPNSs were about 16 and 180 nm, respectively. The hydrogel with the transformation temperature at near body exhibited great photodynamic efficacy and good biodegradability. Moreover, BPNSs/DTX-M-hydrogel with the combination of chemotherapy and photodynamic therapy exhibited unique anticancer efficacy with low toxicity. In conclusion, the combination platform of chemo-photodynamic therapy based on BPNSs could be a prospective strategy in antitumor research. Graphical abstract.

Citing Articles

Emerging 2D Nanomaterials-Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy.

Zorron M, Cabrera A, Sharma R, Radhakrishnan J, Abbaszadeh S, Shahbazi M Adv Sci (Weinh). 2024; 11(31):e2403204.

PMID: 38874422 PMC: 11336986. DOI: 10.1002/advs.202403204.

Hydrogel Breakthroughs in Biomedicine: Recent Advances and Implications.

Mittal R, Mishra R, Uddin R, Sharma V Curr Pharm Biotechnol. 2024; 25(11):1436-1451.

PMID: 38288792 DOI: 10.2174/0113892010281021231229100228.

Injectable Poloxamer Hydrogels for Local Cancer Therapy.

Marques A, Costa P, Velho S, Amaral M Gels. 2023; 9(7).

PMID: 37504472 PMC: 10379388. DOI: 10.3390/gels9070593.

Injectable Thermoresponsive Hydrogels for Cancer Therapy: Challenges and Prospects.

Tanga S, Aucamp M, Ramburrun P Gels. 2023; 9(5).

PMID: 37233009 PMC: 10217649. DOI: 10.3390/gels9050418.

Polymer Gels: Classification and Recent Developments in Biomedical Applications.

Chelu M, Musuc A Gels. 2023; 9(2).

PMID: 36826331 PMC: 9956074. DOI: 10.3390/gels9020161.

References

Sun Y, Ma W, Yang Y, He M, Li A, Bai L . Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy. Asian J Pharm Sci. 2020; 14(6):581-594. PMC: 7032247. DOI: 10.1016/j.ajps.2019.04.005. View

Yu M, Su D, Yang Y, Qin L, Hu C, Liu R . D-T7 Peptide-Modified PEGylated Bilirubin Nanoparticles Loaded with Cediranib and Paclitaxel for Antiangiogenesis and Chemotherapy of Glioma. ACS Appl Mater Interfaces. 2018; 11(1):176-186. DOI: 10.1021/acsami.8b16219. View

Fujiki K, Kanayama Y, Yano S, Sato N, Yokokita T, Ahmadi P . At-labeled immunoconjugate a one-pot three-component double click strategy: practical access to α-emission cancer radiotherapeutics. Chem Sci. 2019; 10(7):1936-1944. PMC: 6385556. DOI: 10.1039/c8sc04747b. View

Korbelik M, Banath J, Zhang W, Hode T, Lam S, Gallagher P . N-dihydrogalactochitosan-supported tumor control by photothermal therapy and photothermal therapy-generated vaccine. J Photochem Photobiol B. 2020; 204:111780. DOI: 10.1016/j.jphotobiol.2020.111780. View

Ma W, Sha S, Chen P, Yu M, Chen J, Huang C . A Cell Membrane-Targeting Self-Delivery Chimeric Peptide for Enhanced Photodynamic Therapy and In Situ Therapeutic Feedback. Adv Healthc Mater. 2019; 9(1):e1901100. DOI: 10.1002/adhm.201901100. View

Yu M, Guo F, Wang J, Tan F, Li N . A pH-Driven and photoresponsive nanocarrier: Remotely-controlled by near-infrared light for stepwise antitumor treatment. Biomaterials. 2015; 79:25-35. DOI: 10.1016/j.biomaterials.2015.11.049. View

Ethirajan M, Chen Y, Joshi P, Pandey R . The role of porphyrin chemistry in tumor imaging and photodynamic therapy. Chem Soc Rev. 2010; 40(1):340-62. DOI: 10.1039/b915149b. View

Chilakamarthi U, Giribabu L . Photodynamic Therapy: Past, Present and Future. Chem Rec. 2017; 17(8):775-802. DOI: 10.1002/tcr.201600121. View

Ge R, Cao J, Chi J, Han S, Liang Y, Xu L . NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy. Int J Nanomedicine. 2019; 14:4931-4947. PMC: 6635674. DOI: 10.2147/IJN.S203171. View

10.

Lu K, He C, Guo N, Chan C, Ni K, Weichselbaum R . Chlorin-Based Nanoscale Metal-Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy. J Am Chem Soc. 2016; 138(38):12502-10. PMC: 5673483. DOI: 10.1021/jacs.6b06663. View

11.

Lu L, Zhao X, Fu T, Li K, He Y, Luo Z . An iRGD-conjugated prodrug micelle with blood-brain-barrier penetrability for anti-glioma therapy. Biomaterials. 2019; 230:119666. DOI: 10.1016/j.biomaterials.2019.119666. View

12.

Zhen S, Yi X, Zhao Z, Lou X, Xia F, Tang B . Drug delivery micelles with efficient near-infrared photosensitizer for combined image-guided photodynamic therapy and chemotherapy of drug-resistant cancer. Biomaterials. 2019; 218:119330. DOI: 10.1016/j.biomaterials.2019.119330. View

13.

Gulzar A, Xu J, Xu L, Yang P, He F, Yang D . Redox-responsive UCNPs-DPA conjugated NGO-PEG-BPEI-DOX for imaging-guided PTT and chemotherapy for cancer treatment. Dalton Trans. 2018; 47(11):3921-3930. DOI: 10.1039/c7dt04093h. View

14.

Bharathiraja S, Manivasagan P, Moorthy M, Bui N, Jang B, Phan T . Photo-based PDT/PTT dual model killing and imaging of cancer cells using phycocyanin-polypyrrole nanoparticles. Eur J Pharm Biopharm. 2017; 123:20-30. DOI: 10.1016/j.ejpb.2017.11.007. View

15.

Li L, Yu Y, Ye G, Ge Q, Ou X, Wu H . Black phosphorus field-effect transistors. Nat Nanotechnol. 2014; 9(5):372-7. DOI: 10.1038/nnano.2014.35. View

16.

Anju S, Ashtami J, Mohanan P . Black phosphorus, a prospective graphene substitute for biomedical applications. Mater Sci Eng C Mater Biol Appl. 2019; 97:978-993. DOI: 10.1016/j.msec.2018.12.146. View

17.

Ding H, Tang Z, Zhang L, Dong Y . Electrogenerated chemiluminescence of black phosphorus nanosheets and its application in the detection of HO. Analyst. 2018; 144(4):1326-1333. DOI: 10.1039/c8an01838c. View

18.

Zong S, Wang L, Yang Z, Wang H, Wang Z, Cui Y . Black Phosphorus-Based Drug Nanocarrier for Targeted and Synergetic Chemophotothermal Therapy of Acute Lymphoblastic Leukemia. ACS Appl Mater Interfaces. 2019; 11(6):5896-5902. DOI: 10.1021/acsami.8b22563. View

19.

Chen L, Zhong X, Yi X, Huang M, Ning P, Liu T . Radionuclide (131)I labeled reduced graphene oxide for nuclear imaging guided combined radio- and photothermal therapy of cancer. Biomaterials. 2015; 66:21-8. DOI: 10.1016/j.biomaterials.2015.06.043. View

20.

Song G, Hao J, Liang C, Liu T, Gao M, Cheng L . Degradable Molybdenum Oxide Nanosheets with Rapid Clearance and Efficient Tumor Homing Capabilities as a Therapeutic Nanoplatform. Angew Chem Int Ed Engl. 2015; 55(6):2122-6. DOI: 10.1002/anie.201510597. View