Clinicopathological Significance of Heat Shock Protein (HSP) 27 Expression in Gastric Cancer: A Updated Meta-Analysis

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2020 Aug 11

PMID 32774426

Citations 4

Authors

Tong Liu

Duo Liu

Xiangxue Kong

Mei Dong

Affiliations

Soon will be listed here.

Abstract

Aim: HSP27 is a protein chaperone protecting cell from heat shock, and upregulated HSP27 expression has been found in many different cancers. We conduct this update meta-analysis to evaluate the relationship between HSP27 expression and clinicopathological features.

Methods: We searched PubMed, Chinese CNKI, and WanFang databases to identify studies that assessed the association between clinicopathological feature and HSP27 expression in gastric cancer patients.

Results: We found overexpression of HSP27 was associated with incidence of gastric cancer (OR = 6.31, 95% CI = 1.10-36.15, < 0.0001). However, there was no significant difference between HSP27 expression and gastric cancer differentiation, gender difference, lymph node metastasis, and distant metastasis.

Conclusion: Our meta-analysis study indicates that overexpression of HSP27 is associated with incidence of gastric cancer statistically.

Citing Articles

, a bridge between oral health and immune evasion in gastric cancer.

Munoz-Medel M, Pinto M, Goralsky L, Caceres M, Villarroel-Espindola F, Manque P Front Oncol. 2024; 14:1403089.

PMID: 38807771 PMC: 11130407. DOI: 10.3389/fonc.2024.1403089.

Ponciri Fructus Immatarus Sensitizes the Apoptotic Effect of Hyperthermia Treatment in AGS Gastric Cancer Cells through ROS-Dependent HSP Suppression.

Ahn C, Kim H, Kim J, Ha I, Ahn K, Park J Biomedicines. 2023; 11(2).

PMID: 36830941 PMC: 9953356. DOI: 10.3390/biomedicines11020405.

Analysis of the prognostic, diagnostic and immunological role of HSP90α in malignant tumors.

Yuan Z, Wang L, Chen C Front Oncol. 2022; 12:963719.

PMID: 36158677 PMC: 9499179. DOI: 10.3389/fonc.2022.963719.

Discovery of Novel HSP27 Inhibitors as Prospective Anti-Cancer Agents Utilizing Computer-Assisted Therapeutic Discovery Approaches.

Umar H, Ajayi A, Mukerjee N, Aborode A, Hasan M, Maitra S Cells. 2022; 11(15).

PMID: 35954254 PMC: 9368632. DOI: 10.3390/cells11152412.

References

Ge H, He X, Guo L, Yang X . Clinicopathological significance of HSP27 in gastric cancer: a meta-analysis. Onco Targets Ther. 2017; 10:4543-4551. PMC: 5602475. DOI: 10.2147/OTT.S146590. View

Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G . Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle. 2006; 5(22):2592-601. DOI: 10.4161/cc.5.22.3448. View

Chatterjee S, Burns T . Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach. Int J Mol Sci. 2017; 18(9). PMC: 5618627. DOI: 10.3390/ijms18091978. View

Takeno S, Noguchi T, Kikuchi R, Sato T, Uchida Y, Yokoyama S . Analysis of the survival period in resectable stage IV gastric cancer. Ann Surg Oncol. 2001; 8(3):215-21. DOI: 10.1007/s10434-001-0215-1. View

Xanthoudakis S, Roy S, Rasper D, Hennessey T, Aubin Y, Cassady R . Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis. EMBO J. 1999; 18(8):2049-56. PMC: 1171289. DOI: 10.1093/emboj/18.8.2049. View

Samali A, Cai J, Zhivotovsky B, Jones D, Orrenius S . Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells. EMBO J. 1999; 18(8):2040-8. PMC: 1171288. DOI: 10.1093/emboj/18.8.2040. View

Chauhan D, Li G, Hideshima T, Podar K, Mitsiades C, Mitsiades N . Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. Blood. 2003; 102(9):3379-86. DOI: 10.1182/blood-2003-05-1417. View

Jego G, Hazoume A, Seigneuric R, Garrido C . Targeting heat shock proteins in cancer. Cancer Lett. 2010; 332(2):275-85. DOI: 10.1016/j.canlet.2010.10.014. View

Choi S, Kam H, Kim K, Park S, Lee Y . Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?. Cancers (Basel). 2019; 11(8). PMC: 6721579. DOI: 10.3390/cancers11081195. View

10.

Kapranos N, Kominea A, Konstantinopoulos P, Savva S, Artelaris S, Vandoros G . Expression of the 27-kDa heat shock protein (HSP27) in gastric carcinomas and adjacent normal, metaplastic, and dysplastic gastric mucosa, and its prognostic significance. J Cancer Res Clin Oncol. 2002; 128(8):426-32. DOI: 10.1007/s00432-002-0357-y. View

11.

Arrigo A, Gibert B . HspB1 dynamic phospho-oligomeric structure dependent interactome as cancer therapeutic target. Curr Mol Med. 2012; 12(9):1151-63. DOI: 10.2174/156652412803306693. View

12.

Kennedy D, Jager R, Mosser D, Samali A . Regulation of apoptosis by heat shock proteins. IUBMB Life. 2014; 66(5):327-38. DOI: 10.1002/iub.1274. View

13.

Calderwood S, Gong J . Heat Shock Proteins Promote Cancer: It's a Protection Racket. Trends Biochem Sci. 2016; 41(4):311-323. PMC: 4911230. DOI: 10.1016/j.tibs.2016.01.003. View

14.

Bodoor K, Jalboush S, Matalka I, Abu-Sheikha A, Waq R, Ebwaini H . Heat Shock Protein Association with Clinico-Pathological Characteristics of Gastric Cancer in Jordan : HSP70 is Predictive of Poor Prognosis. Asian Pac J Cancer Prev. 2016; 17(8):3929-37. View

15.

Ang T, Fock K . Clinical epidemiology of gastric cancer. Singapore Med J. 2015; 55(12):621-8. PMC: 4291998. DOI: 10.11622/smedj.2014174. View

16.

Yang L, Zheng R, Wang N, Yuan Y, Liu S, Li H . Incidence and mortality of stomach cancer in China, 2014. Chin J Cancer Res. 2018; 30(3):291-298. PMC: 6037587. DOI: 10.21147/j.issn.1000-9604.2018.03.01. View

17.

Singh M, Sharma B, Tiwari P . The small heat shock protein Hsp27: Present understanding and future prospects. J Therm Biol. 2017; 69:149-154. DOI: 10.1016/j.jtherbio.2017.06.004. View