Assessing the Potential for Unintended Microbial Consequences of Routine Chlorhexidine Bathing for Prevention of Healthcare-associated Infections
Overview
Affiliations
Chlorhexidine gluconate (CHG) is an antiseptic that is widely used in healthcare due to its excellent safety profile and wide spectrum of activity. Daily bathing with CHG has proven to be effective in the prevention of healthcare-associated infections and multidrug-resistant pathogen decolonization. Despite the proven benefits of CHG use, there remain concerns and unanswered questions about the potential for unintended microbial consequences of routine CHG bathing. This review aims to explore some of these questions.
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Lydecker A, Kim J, Robinson G, Johnson J, Brown C, Petruccelli C JAMA Netw Open. 2025; 8(2):e2460087.
PMID: 39964684 PMC: 11836759. DOI: 10.1001/jamanetworkopen.2024.60087.
Chang H, Liu T, Huang P, Chen C, Yen C, Chen H Microorganisms. 2025; 13(1).
PMID: 39858834 PMC: 11767414. DOI: 10.3390/microorganisms13010065.
Qian J, Lin J, Liu J, Gong Y, Zheng S, Mei L Int J Surg. 2024; 111(1):697-705.
PMID: 39172724 PMC: 11745714. DOI: 10.1097/JS9.0000000000002052.
Dinu S, Matichescu A, Buzatu R, Marcovici I, Geamantan-Sirbu A, Semenescu A Dent J (Basel). 2024; 12(7).
PMID: 39057008 PMC: 11276539. DOI: 10.3390/dj12070221.
Mangalea M, Halpin A, Haile M, Elkins C, McDonald L Emerg Infect Dis. 2024; 30(6):1069-1076.
PMID: 38781679 PMC: 11138981. DOI: 10.3201/eid3006.231338.