Emerging Roles and Therapeutic Interventions of Aerobic Glycolysis in Glioma

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2020 Aug 9

PMID 32764985

Citations 17

Authors

Wei Han

Jia Shi

Jiachao Cao

Bo Dong

Wei Guan

Affiliations

Soon will be listed here.

Abstract

Glioma is the most common type of intracranial malignant tumor, with a great recurrence rate due to its infiltrative growth, treatment resistance, intra- and intertumoral genetic heterogeneity. Recently, accumulating studies have illustrated that activated aerobic glycolysis participated in various cellular and clinical activities of glioma, thus influencing the efficacy of radiotherapy and chemotherapy. However, the glycolytic process is too complicated and ambiguous to serve as a novel therapy for glioma. In this review, we generalized the implication of key enzymes, glucose transporters (GLUTs), signalings and transcription factors in the glycolytic process of glioma. In addition, we summarized therapeutic interventions via the above aspects and discussed promising clinical applications for glioma.

Citing Articles

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Glucose metabolism in glioma: an emerging sight with ncRNAs.

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