Coronavirus Diseases 2019: Current Biological Situation and Potential Therapeutic Perspective

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 2020 Aug 9

PMID 32763302

Citations 17

Authors

Suliman Khan

Huseyin Tombuloglu

Sameh E Hassanein

Suriya Rehman

Ayhan Bozkurt

Emre Cevik

Shaimaa Abdel-Ghany

Ghulam Nabi

Ashaq Ali

Hussein Sabit

Affiliations

Soon will be listed here.

Abstract

Coronavirus Disease 2019 (COVID-19) caused by a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was first reported in Wuhan, China at the end of December 2019. SARS-CoV-2 is a highly pathogenic zoonotic virus and closely related to the Severe Acute Respiratory Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The COVID-19 was declared as a global pandemic due to its high infectiousness, and worldwide morbidities and mortalities. The Chinese scientists at the start of the outbreak reported genome sequences, which made the characterization of glycoproteins and other structural proteins possible. Moreover, researchers across the world have widely focused on understanding basic biology, developing vaccines, and therapeutic drugs against the COVID-19. However, until now, no promising treatment options, as well as vaccines, are available. In this review, we have described SARS-CoV-2's genome, transmission, and pathogenicity. We also discussed novel potential therapeutic agents that can help to treat the COVID-19 patients.

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