Defining Gaps in Pre-exposure Prophylaxis Delivery for Pregnant and Post-partum Women in High-burden Settings Using an Implementation Science Framework

Overview

Journal Lancet HIV

Specialty Infectious Diseases

Date 2020 Aug 9

PMID 32763221

Citations 39

Authors

Jillian Pintye

Dvora L Joseph Davey

Anjuli D Wagner

Grace John-Stewart

Rachel Baggaley

Linda-Gail Bekker

Connie Celum

Benjamin H Chi

Thomas J Coates

Allison K Groves

Jessica E Haberer

Renee Heffron

John Kinuthia

Lynn T Matthews

James A McIntyre

Dhayendre Moodley

Lynne M Mofenson

Nelly Mugo

Andrew Mujugira

Landon Myer

Steven Shoptaw

Lynda Stranix-Chibanda

Jared M Baeten

Affiliations

Soon will be listed here.

Abstract

Pregnancy is a high-risk period for HIV acquisition in African women, and pregnant women who become acutely infected with HIV account for up to a third of vertical HIV transmission cases in African settings. To protect women and eliminate vertical transmission, WHO recommends offering oral pre-exposure prophylaxis (PrEP) based on tenofovir to HIV-negative pregnant and post-partum women with a substantial risk of HIV acquisition. PrEP implementation for pregnant and post-partum women lags behind implementation for other high-risk populations. Unique considerations for PrEP implementation arise during pregnancy and post partum, including the integration of provider training with clinical delivery and monitoring of PrEP exposure and outcomes within existing maternal health systems, yet scarce implementation data are available to generate evidence in this context.

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