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CRISPR/Cas: a Potential Gene-editing Tool in the Nervous System

Overview
Journal Cell Regen
Publisher Springer
Date 2020 Aug 8
PMID 32761306
Citations 4
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Abstract

The rapidly developmental RNA-guided CRISPR/Cas system is a powerful tool for RNA and DNA editing in a variety of cells from different species and makes a great contribution to gene function research, disease model generation and gene therapy development in the past few years. The ease of use, low cost and high efficiency of CRISPR/Cas make it commonly used in various conditions. In this review, we introduce the CRISPR/Cas system and its diverse applications in nervous system briefly, which provides a better understanding for its potential application values.

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References
1.
Mandegar M, Huebsch N, Frolov E, Shin E, Truong A, Olvera M . CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Cell Stem Cell. 2016; 18(4):541-53. PMC: 4830697. DOI: 10.1016/j.stem.2016.01.022. View

2.
Zetsche B, Heidenreich M, Mohanraju P, Fedorova I, Kneppers J, DeGennaro E . Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array. Nat Biotechnol. 2016; 35(1):31-34. PMC: 5225075. DOI: 10.1038/nbt.3737. View

3.
Zentner G, Henikoff S . Epigenome editing made easy. Nat Biotechnol. 2015; 33(6):606-7. DOI: 10.1038/nbt.3248. View

4.
Zuo E, Cai Y, Li K, Wei Y, Wang B, Sun Y . One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs. Cell Res. 2017; 27(7):933-945. PMC: 5518993. DOI: 10.1038/cr.2017.81. View

5.
Liu J, Gao C, Chen W, Ma W, Li X, Shi Y . CRISPR/Cas9 facilitates investigation of neural circuit disease using human iPSCs: mechanism of epilepsy caused by an SCN1A loss-of-function mutation. Transl Psychiatry. 2016; 6:e703. PMC: 5068877. DOI: 10.1038/tp.2015.203. View