Current Knowledge on the Function of α-Methyl Acyl-CoA Racemase in Human Diseases

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2020 Aug 8

PMID 32760737

Citations 8

Authors

Gyeyeong Kong

Hyunji Lee

Quangdon Tran

Chaeyeong Kim

Nayoung Gong

Jisoo Park

So Hee Kwon

Seon-Hwan Kim

Jongsun Park

Affiliations

Soon will be listed here.

Abstract

Branched chain fatty acids perform very important functions in human diet and drug metabolism. they cannot be metabolized in mitochondria and are instead processed and degraded in peroxisomes due to the presence of methyl groups on the carbon chains. Oxidative degradation pathways for lipids include α- and β-oxidation and several pathways. In all metabolic pathways, α-methyl acyl-CoA racemase (AMACR) plays an essential role by regulating the metabolism of lipids and drugs. AMACR regulates β-oxidation of branched chain lipids in peroxisomes and mitochondria and promotes chiral reversal of 2-methyl acids. AMACR defects cause sensory-motor neuronal and liver abnormalities in humans. These phenotypes are inherited and are caused by mutations in AMACR. In addition, AMACR has been found to be overexpressed in prostate cancer. In addition, the protein levels of AMACR have increased significantly in many types of cancer. Therefore, AMACR may be an important marker in tumors. In this review, a comprehensive overview of AMACR studies in human disease will be described.

Citing Articles

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