Vitamin B Supplementation and NT-proBNP Levels in COPD Patients: A Secondary Analysis of a Randomized and Controlled Study in Rehabilitation

Overview

Journal Front Neurosci

Date 2020 Aug 8

PMID 32760247

Citations 4

Authors

Fernanda Viana Paulin

Leandro Steinhorst Goelzer

Paulo de Tarso Muller

Affiliations

Soon will be listed here.

Abstract

Purpose: There is evidence of complex interaction between vitamin B (vB) level, hyperhomocysteinemia (HyCy), and natriuretic peptide secretion. Exercise training could also modulate such interaction. In this secondary analysis of a Randomized Clinical Trial performed in a chronic obstructive pulmonary disease (COPD) rehabilitation setting, our primary objective was to investigate the interaction between vB supplementation, exercise training, and changes in NT-proBNP levels after 8 weeks of intervention. Secondary objectives were to explore the correlations between acute changes in NT-proBNP levels with (i) acute exercise and (ii) oxygen uptake ('O) kinetics during rest-to-exercise transition.

Methods: Thirty-two subjects with COPD were randomized into four groups: Rehabilitation+vB ( = 8), Rehabilitation ( = 8), vB ( = 8), or Maltodextrin( = 8). They were evaluated at baseline and after 8 weeks, during resting and immediately after maximal exercise constant work-rate tests (CWTs, lim), for NT-proBNP plasmatic levels.

Results: After interaction analysis, the supplementation with vB significantly changed the time course of NT-proBNP responses during treatment ( = 0.048). However, the final analysis could not support a significant change in NT-proBNP levels owing to high-intensity constant work-rate exercise (-value > 0.05). There was a statistically significant correlation between 'O time constant and ΔNT-proBNP values (lim - rest) at baseline ( = 0.049) and 2 months later ( = 0.015), considering all subjects ( = 32).

Conclusion: We conclude that vB supplementation could modulate NT-proBNP secretion. Moreover, possibly, the slower the initial 'O adjustments toward a steady-state during rest-to-exercise transitions, the more severe the ventricular chamber volume/pressure stress recruitment, expressed through higher NT-proBNP secretion in subjects with larger 'O time constants, despite unchanged final acute exercise-induced neurohormone secretion.

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