Role of Hippo-YAP1/TAZ Pathway and Its Crosstalk in Cardiac Biology

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2020 Aug 8

PMID 32760212

Citations 12

Authors

Xiaoqing Chen

Wenchang Yuan

Yilang Li

Jiandong Luo

Ning Hou

Affiliations

Soon will be listed here.

Abstract

The Hippo pathway undertakes a pivotal role in organ size control and the process of physiology and pathology in tissue. Its downstream effectors YAP1 and TAZ receive upstream stimuli and exert transcription activity to produce biological output. Studies have demonstrated that the Hippo pathway contributes to maintenance of cardiac homeostasis and occurrence of cardiac disease. And these cardiac biological events are affected by crosstalk among Hippo-YAP1/TAZ, Wnt/β-catenin, Bone morphogenetic protein (BMP) and G-protein-coupled receptor (GPCR) signaling, which provides new insights into the Hippo pathway in heart. This review delineates the interaction among Hippo, Wnt, BMP and GPCR pathways and discusses the effects of these pathways in cardiac biology.

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References

Akladios B, Mendoza-Reinoso V, Samuel M, Hardeman E, Khosrotehrani K, Key B . Epidermal YAP2-5SA-ΔC Drives β-Catenin Activation to Promote Keratinocyte Proliferation in Mouse Skin In Vivo. J Invest Dermatol. 2016; 137(3):716-726. DOI: 10.1016/j.jid.2016.10.029. View

Mo J . The role of extracellular biophysical cues in modulating the Hippo-YAP pathway. BMB Rep. 2016; 50(2):71-78. PMC: 5342869. DOI: 10.5483/bmbrep.2017.50.2.199. View

Klaus A, Saga Y, Taketo M, Tzahor E, Birchmeier W . Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis. Proc Natl Acad Sci U S A. 2007; 104(47):18531-6. PMC: 2141811. DOI: 10.1073/pnas.0703113104. View

Feng X, Arang N, Rigiracciolo D, Lee J, Yeerna H, Wang Z . A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell. 2019; 35(3):457-472.e5. PMC: 6737937. DOI: 10.1016/j.ccell.2019.01.009. View

Levy D, Adamovich Y, Reuven N, Shaul Y . Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell. 2008; 29(3):350-61. DOI: 10.1016/j.molcel.2007.12.022. View

Heallen T, Morikawa Y, Leach J, Tao G, Willerson J, Johnson R . Hippo signaling impedes adult heart regeneration. Development. 2013; 140(23):4683-90. PMC: 3833428. DOI: 10.1242/dev.102798. View

Bae J, Jeon Y, Kim S, Jang J, Park M, Kim I . Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling. Cell Death Dis. 2018; 9(11):1083. PMC: 6197243. DOI: 10.1038/s41419-018-1138-0. View

Xu F, Wang Y, Chang J, Du S, Diao L, Jiang N . Mammalian sterile 20-like kinase 1/2 inhibits the Wnt/β-catenin signalling pathway by directly binding casein kinase 1ε. Biochem J. 2013; 458(1):159-69. DOI: 10.1042/BJ20130986. View

Xiong J, Almeida M, OBrien C . The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation. Bone. 2018; 112:1-9. PMC: 5970058. DOI: 10.1016/j.bone.2018.04.001. View

10.

Feng Y, Liang Y, Zhu X, Wang M, Gui Y, Lu Q . The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz. J Biol Chem. 2018; 293(50):19290-19302. PMC: 6302175. DOI: 10.1074/jbc.RA118.005457. View

11.

An J, Li G, Zhang J, Zhou H, Jiang J, Wang X . GNAS knockdown suppresses osteogenic differentiation of mesenchymal stem cells via activation of Hippo signaling pathway. J Cell Physiol. 2019; 234(12):22299-22310. DOI: 10.1002/jcp.28796. View

12.

Van Kolen K, Slegers H . Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networks. Purinergic Signal. 2008; 2(3):451-69. PMC: 2254474. DOI: 10.1007/s11302-006-9008-0. View

13.

Lin Z, Zhou P, von Gise A, Gu F, Ma Q, Chen J . Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ Res. 2014; 116(1):35-45. PMC: 4282610. DOI: 10.1161/CIRCRESAHA.115.304457. View

14.

Wang J, Sinnett-Smith J, Stevens J, Young S, Rozengurt E . Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD). J Biol Chem. 2016; 291(34):17988-8005. PMC: 5016186. DOI: 10.1074/jbc.M115.711275. View

15.

Chan E, Nousiainen M, Chalamalasetty R, Schafer A, Nigg E, Sillje H . The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene. 2005; 24(12):2076-86. DOI: 10.1038/sj.onc.1208445. View

16.

Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S . YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell. 2014; 158(1):157-70. DOI: 10.1016/j.cell.2014.06.013. View

17.

Moroishi T, Park H, Qin B, Chen Q, Meng Z, Plouffe S . A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 2015; 29(12):1271-84. PMC: 4495398. DOI: 10.1101/gad.262816.115. View

18.

Xin M, Kim Y, Sutherland L, Murakami M, Qi X, McAnally J . Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A. 2013; 110(34):13839-44. PMC: 3752208. DOI: 10.1073/pnas.1313192110. View

19.

Suzuki Y, Montagne K, Nishihara A, Watabe T, Miyazono K . BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling. J Biochem. 2007; 143(2):199-206. DOI: 10.1093/jb/mvm215. View

20.

Regue L, Mou F, Avruch J . G protein-coupled receptors engage the mammalian Hippo pathway through F-actin: F-Actin, assembled in response to Galpha12/13 induced RhoA-GTP, promotes dephosphorylation and activation of the YAP oncogene. Bioessays. 2013; 35(5):430-5. PMC: 4092039. DOI: 10.1002/bies.201200163. View