DNA Methylation in Hepatoblastoma-a Literature Review

Overview

Journal Ital J Pediatr

Publisher Biomed Central

Specialty Pediatrics

Date 2020 Aug 8

PMID 32758256

Citations 8

Authors

Gang Shen

Hongyu Shen

Jing Zhang

Qingtao Yan

Huixian Liu

Affiliations

Soon will be listed here.

Abstract

Hepatoblastoma (HB) is the most common malignant liver tumor in children. Abnormal activation of the Wnt/β-catenin signaling pathway plays an important role in the formation and development of HB. Genes in HB show a global hypomethylation change, accompanied by hypermethylation of specific tumor suppressor genes (TSGs). This article reviews the hypermethylation changes in several TSGs, such as RASSF1A, SOCS1, APC, HHIP, and P16, and analyzes the pathways and mechanisms of TSGs regulating gene expression. The role of the methylation-regulating enzymes DNA methyltransferases (DNMTs) and ten-eleven translocation (TET) family members enzymes in the methylation changes of HB was analyzed, and it was speculated that the occurrence of HB is partly due to the obstruction of liver differentiation in the early stage of differentiation. The origin cells may be incompletely differentiated hepatocytes remaining in the liver of children after birth. Therefore, further studying the role of methylation regulating enzymes in methylation changes in HB is a promising future research direction.

Citing Articles

Characterization of an Activated Metabolic Transcriptional Program in Hepatoblastoma Tumor Cells Using scRNA-seq.

Monge C, Frances R, Marchio A, Pineau P, Desterke C, Mata-Garrido J Int J Mol Sci. 2024; 25(23).

PMID: 39684755 PMC: 11641740. DOI: 10.3390/ijms252313044.

High-Resolution Magic-Angle-Spinning NMR in Revealing Hepatoblastoma Hallmarks.

Tasic L, Avramovic N, Jadranin M, Quintero M, Stanisic D, Martins L Biomedicines. 2022; 10(12).

PMID: 36551847 PMC: 9775661. DOI: 10.3390/biomedicines10123091.

Epigenetics and genetics of hepatoblastoma: Linkage and treatment.

Zhu L, Zheng W, Gao Q, Chen T, Pan Z, Cui W Front Genet. 2022; 13:1070971.

PMID: 36531231 PMC: 9748487. DOI: 10.3389/fgene.2022.1070971.

The Role of N-Methyladenosine in the Promotion of Hepatoblastoma: A Critical Review.

Auld F, Sergi C, Leng R, Shen F Cells. 2022; 11(9).

PMID: 35563821 PMC: 9101889. DOI: 10.3390/cells11091516.

Surgical Pathology Diagnostic Pitfalls of Hepatoblastoma.

Auld F, Sergi C Int J Surg Pathol. 2022; 30(5):480-491.

PMID: 35048730 PMC: 9260486. DOI: 10.1177/10668969211070178.

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