MMP-9-C1562T Polymorphism and Susceptibility to Chronic Obstructive Pulmonary Disease: A Meta-analysis

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2020 Aug 7

PMID 32756173

Citations 3

Authors

Rongrong Zhao

Houxiu Zhou

Jingci Zhu

Affiliations

Soon will be listed here.

Abstract

Background: To comprehensively evaluate the association between the polymorphism of matrix metalloproteinase-9 (MMP-9)-C1562T (rs3918242) and susceptibility to chronic obstructive pulmonary disease (COPD) in middle-aged and elderly patients through Meta-analysis.

Methods: PubMed, EMBASE, CNKI, Wanfang, VIP, and other databases were searched by computer in the inception to August 2019 to collect all the case-control studies that met the inclusion criteria in this literature. Meta-analysis was performed using Stata 15.0, including the OR value calculations of the association between the merged MMP-9-C1562T polymorphism and the COPD susceptibility. Subgroup analysis, sensitivity analysis, and publication bias test were also performed. A total of 13 literature were included in this Meta-analysis with a total of 2512 cases and 2716 controls.

Results: The results have shown that the OR of MMP-9-C1562T T allele to C allele was 0.35 (95% confidence interval [CI]: 0.23-0.52, P < .01). The subgroup analysis of ethnicity result showed that the merged OR of MMP-9-C1562T T allele to C allele was 0.24 (95% CI: 0.17-0.34, P < .01) in Caucasian while the merged OR was 0.62 (95% CI: 0.22-1.70, P > .05) in Asian. However, there were no statistically significant models in the dominant, recessive, homozygote and heterozygote genetic models.

Conclusion: The MMP-9-C1562T polymorphism was associated with the susceptibility to middle-aged and elderly COPD patients. Compared with T allele, C allele increased the risk of disease, especially in Caucasian, but not found in Asian.

Citing Articles

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References

Cheng S, Yu C, Yang P . Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease. Biochem Genet. 2009; 47(7-8):591-601. DOI: 10.1007/s10528-009-9252-4. View

Minematsu N, Nakamura H, Tateno H, Nakajima T, Yamaguchi K . Genetic polymorphism in matrix metalloproteinase-9 and pulmonary emphysema. Biochem Biophys Res Commun. 2001; 289(1):116-9. DOI: 10.1006/bbrc.2001.5936. View

Korytina G, Akhmadishina L, Ianbaeva D, Viktorova T . [Polymorphism in promoter regions of matrix metalloproteinases (MMP1, MMP9, and MMP12) in chronic obstructive pulmonary disease patients]. Genetika. 2008; 44(2):242-9. View

Wang C, Xu J, Yang L, Xu Y, Zhang X, Bai C . Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet. 2018; 391(10131):1706-1717. DOI: 10.1016/S0140-6736(18)30841-9. View

Aggarwal T, Wadhwa R, Rohil V, Maurya P . Biomarkers of oxidative stress and protein-protein interaction in chronic obstructive pulmonary disease. Arch Physiol Biochem. 2017; 124(3):226-231. DOI: 10.1080/13813455.2017.1387796. View

Schirmer H, Basso da Silva L, Teixeira P, Moreira J, Moreira A, Simon D . Matrix metalloproteinase gene polymorphisms: lack of association with chronic obstructive pulmonary disease in a Brazilian population. Genet Mol Res. 2009; 8(3):1028-34. DOI: 10.4238/vol8-3gmr596. View

Navratilova Z, Kolek V, Petrek M . Matrix Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease. Arch Immunol Ther Exp (Warsz). 2015; 64(3):177-93. DOI: 10.1007/s00005-015-0375-5. View

Vempati P, Karagiannis E, Popel A . A biochemical model of matrix metalloproteinase 9 activation and inhibition. J Biol Chem. 2007; 282(52):37585-96. DOI: 10.1074/jbc.M611500200. View

Ni W, Ding H, Zhou H, Qiu Y, Tang L . Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in rats. Eur J Pharmacol. 2015; 764:448-456. DOI: 10.1016/j.ejphar.2015.07.040. View

10.

Busch R, Hobbs B, Zhou J, Castaldi P, McGeachie M, Hardin M . Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects. Am J Respir Cell Mol Biol. 2017; 57(1):35-46. PMC: 5516277. DOI: 10.1165/rcmb.2016-0331OC. View

11.

Chen L, Wang T, Liu L, Shen Y, Wan C, Wen F . Matrix metalloproteinase-9 -1562C/T promoter polymorphism confers risk for COPD: a meta-analysis. PLoS One. 2013; 8(3):e60523. PMC: 3610819. DOI: 10.1371/journal.pone.0060523. View

12.

Golpe R, Sanjuan-Lopez P, Martin-Robles I, Gonzalez-Juanatey C, Perez-de-Llano L, Lopez-Campos J . Cardiovascular Studies in Patients with Chronic Obstructive Pulmonary Disease Due to Biomass Smoke or Tobacco. Lung. 2018; 196(2):195-200. DOI: 10.1007/s00408-018-0095-9. View

13.

Xia S, Qu J, Jia H, He W, Li J, Zhao L . Overexpression of Forkhead box C1 attenuates oxidative stress, inflammation and apoptosis in chronic obstructive pulmonary disease. Life Sci. 2018; 216:75-84. DOI: 10.1016/j.lfs.2018.11.023. View

14.

Zhou M, Huang S, Wan H, Li B, Deng W, Li M . Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China. Chin Med J (Engl). 2004; 117(10):1481-4. View

15.

Stang A . Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010; 25(9):603-5. DOI: 10.1007/s10654-010-9491-z. View

16.

Gilowska I, Kasper L, Bogacz K, Szczegielniak J, Szymasek T, Kasper M . Impact of Matrix Metalloproteinase 9 on COPD Development in Polish Patients: Genetic Polymorphism, Protein Level, and Their Relationship with Lung Function. Biomed Res Int. 2019; 2018:6417415. PMC: 6311264. DOI: 10.1155/2018/6417415. View

17.

Zhou L, Le Y, Tian J, Yang X, Jin R, Gai X . Cigarette smoke-induced RANKL expression enhances MMP-9 production by alveolar macrophages. Int J Chron Obstruct Pulmon Dis. 2018; 14:81-91. PMC: 6304243. DOI: 10.2147/COPD.S190023. View

18.

Lee S, Kim M, Kang H, Yoo S, Choi Y, Lee W . Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population. Respiration. 2010; 80(2):133-8. DOI: 10.1159/000284926. View

19.

Ma H, Li W, Liu X . Matrix metalloproteinase 9 is involved in airway inflammation in cough variant asthma. Exp Ther Med. 2014; 8(4):1197-1200. PMC: 4151709. DOI: 10.3892/etm.2014.1903. View

20.

Peppin G, Weiss S . Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils. Proc Natl Acad Sci U S A. 1986; 83(12):4322-6. PMC: 323724. DOI: 10.1073/pnas.83.12.4322. View