The Dysregulation and Prognostic Analysis of STRIPAK Complex Across Cancers

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2020 Aug 6

PMID 32754603

Citations 7

Authors

Ruiling Xie

Feng Wen

Yong Qin

Affiliations

Soon will be listed here.

Abstract

The striatin-interacting phosphatase and kinase (STRIPAK) is the highly conserved complex, which gains increased attention in physiology and pathology process recently. However, limited studies reported the details of STRIPAK complex in cancers while some results strongly suggested it plays a vital role in tumorigenesis. Hence, we systematically analyzed the molecular and survival profiles of 18 STRIPAK genes to assess the value of STRIPAK complex across cancers. Our findings revealed the low frequencies of DNA aberrances and incomparable expression difference of STRIPAK genes between normal and tumor tissues, but they showed strong prognostic value in cancers, especially the liver hepatocellular carcinoma (LIHC) and kidney renal clear cell carcinoma (KIRC). Interestingly, STRIPAK genes were observed the opposite pattern of survival and expression in the above two cancer types. PPP2R1A and TRAF3IP3 were proposed as the oncogenic genes in LIHC and KIRC, respectively. The STRIPAK genes serve as oncogenes may due to the methylation heterogeneity. Taken together, our comprehensive molecular analysis of STRIPAK complex provides resource to facilitate the understanding of mechanism and utilize the potential therapies to tumors.

Citing Articles

STRIPAK, a fundamental signaling hub of eukaryotic development.

Kuck U, Poggeler S Microbiol Mol Biol Rev. 2024; 88(4):e0020523.

PMID: 39526753 PMC: 11653735. DOI: 10.1128/mmbr.00205-23.

Cellular Impacts of Striatins and the STRIPAK Complex and Their Roles in the Development and Metastasis in Clinical Cancers (Review).

Li A, Martin T, Lane J, Jiang W Cancers (Basel). 2024; 16(1).

PMID: 38201504 PMC: 10777921. DOI: 10.3390/cancers16010076.

Striatins and STRIPAK complex partners in clinical outcomes of patients with breast cancer and responses to drug treatment.

Li A, Zeng J, Martin T, Ye L, Ruge F, Sanders A Chin J Cancer Res. 2023; 35(4):365-385.

PMID: 37691891 PMC: 10485918. DOI: 10.21147/j.issn.1000-9604.2023.04.04.

STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent.

Zhang X, Chen Q, He Y, Shi Q, Yin C, Xie Y J Exp Clin Cancer Res. 2023; 42(1):19.

PMID: 36639675 PMC: 9837939. DOI: 10.1186/s13046-022-02573-1.

Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers.

An L, Cao Z, Nie P, Zhang H, Tong Z, Chen F J Clin Invest. 2022; 132(9).

PMID: 35290241 PMC: 9057599. DOI: 10.1172/JCI155468.

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